175026-96-7 Usage
Description
Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.
Uses
NQDI-1 is an ASK1 inhibitor which is of therapeutic potential against acute ischemic renal injury. ?Its protective effects are mediated through inhibition of apoptosis and oxidative stress.
References
Volynets et al. (2011), Identification of 2H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1); Med. Chem., 54 2680
Nomura et al. (2013), An ASK1-p38 signaling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells; Lett., 549 163
Chen et al. (2019), The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage; J. Pharmacol., 176 1341
Ma et al. (2019), Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress associated pathways; Exp. Clin. Cancer Res., 38 77
Feng et al. (2018), Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway; Cell Death Discov., 4 47
Check Digit Verification of cas no
The CAS Registry Mumber 175026-96-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,0,2 and 6 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 175026-96:
(8*1)+(7*7)+(6*5)+(5*0)+(4*2)+(3*6)+(2*9)+(1*6)=137
137 % 10 = 7
So 175026-96-7 is a valid CAS Registry Number.
175026-96-7Relevant articles and documents
Synthesis of 7-oxo-7H-naphtho[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines
Dzieduszycka, Maria,Bontemps-Gracz, Maria M.,Stefanska, Barbara,Martelli, Sante,Piwkowska, Agnieszka,Arciemiuk, Malgorzata,Borowski, Edward
, p. 2880 - 2886 (2007/10/03)
Following our earlier finding that tetracyclic anthraquinone analogs with a fused pyridone ring exhibit cytotoxic activity toward multidrug resistant tumor cells, a series of new potential antitumor agents, 7-oxo-7H-naphtho[1,2,3-de] quinoline derivatives (3, 6-8, 10-12, 14, 15, and 18), bearing one or two basic side chains and various substituents at the pyridone ring, have been synthesized. The compounds have been obtained from 1-amino-4-chloroanthraquinone or 1-aminoanthraquinone by cyclization with diethyl malonate and the subsequent reactions of the key intermediates 2, 4, and 17. The compounds exhibited cytotoxic activity toward sensitive human leukemia cell line HL-60 and against its resistant sublines HL-60/VINC (MDR1 type) and HL-60/DX (MRP1 type).
Synthesis of novel substituted anthra [1,9-bc]pyridin-6-ones
Berghot,Moawad
, p. 564 - 5568 (2007/10/03)
Anthrapyridone derivative 5a was formed as a result of cyclohydrolysis of 2 which was obtained from the reaction of 1 with malononitrile, anthrapyridone 5e, 5f and 5g were also formed from cyclization reaction of the prepared new derivative 3, 4a and 4b respectively in basic conditions. While anthrapyridone derivative 5b, 5c and 5d were prepared directly from the reaction of 1 with benzylcyanide, phenyl acetaldehyde and diethyl malonate respectively.
