175075-24-8

Basic information

• Product Name: 5-Aminosulfonyl-2-Ox-Indole
• Synonyms: 5-Aminosulfonyl-2-Ox-Indole;2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide;2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide;2-Oxoindoline-5-sulfonamide;5-Aminosulfonyl-2-indolinone
• CAS NO: 175075-24-8
• Molecular Formula: C₈H₈N₂O₃S
• Molecular Weight: 212.23
• Product Categories: Chemical Amines;Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 175075-24-8.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• Density: 1.516g/cm³
• Refractive Index: 1.636
• Solubility: Dichloromethane, DMSO, THF
• PKA: 9.82±0.20(Predicted)
• CAS DataBase Reference: 5-Aminosulfonyl-2-Ox-Indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Aminosulfonyl-2-Ox-Indole(175075-24-8)
• EPA Substance Registry System: 5-Aminosulfonyl-2-Ox-Indole(175075-24-8)

Safety Data

• Hazardous Substances Data: 175075-24-8(Hazardous Substances Data)

Usage

Chemical Properties

Light-Brown Solid

Uses

2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide (cas# 175075-24-8) is a compound useful in organic synthesis.

InChI:InChI=1/C8H8N2O3S/c9-14(12,13)6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)(H2,9,12,13)

Upstream product

• 199328-31-9 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride 
• 59-48-3 2-oxoindole 
• 175075-25-9 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 

Downstream Products

• 181223-16-5 3-(1H-indol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide 
• 622387-85-3 SyK inhibitor 

Relevant articles and documents

FORMULATIONS FOR PHARMACEUTICAL AGENTS IONIZABLE AS FREE ACIDS OR FREE BASES

-

Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors

The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.

Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)

The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.