175085-04-8

Basic information

• Product Name: (S)-2-methoxy-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate
• Synonyms: (S)-2-methoxy-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate
• CAS NO: 175085-04-8
• Molecular Weight: 348.396
• Mol File: 175085-04-8.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-methoxy-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-methoxy-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate(175085-04-8)
• EPA Substance Registry System: (S)-2-methoxy-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate(175085-04-8)

Safety Data

• Hazardous Substances Data: 175085-04-8(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 175085-05-9 (S)-2-(benzoyloxy)-2-((2R,5R,6R)-tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2H-pyran-2-yl)acetic acid 
• 250378-76-8 tert-Butyl syn-(4S,5R)-5-hydroxy-4-methyl-3-oxohexanoate 
• 98-88-4 benzoyl chloride 
• 1083401-50-6 (3S,4R)-3,4-dimethyloxetan-2-one 
• 1336892-19-3 C₁₃H₂₄O₃S₂ 
• 75-11-6 diiodomethane 
• 855282-15-4 Benzoic acid (R)-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethyl ester 
• 855282-47-2 (R)-1-((2R,5R,6R)-2-Methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethanol 
• 855282-45-0 (R)-1-((2R,5R,6R)-tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2H-pyran-2-yl)ethane-1,2-diol 
• 250378-78-0 (S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate 
• 250378-77-9 methyl (S)-2-hydroxy-2-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)acetate 
• 250378-69-9 (S)-2-methoxy-1-((2R,5S,6R)-2-methoxy-5,6-dimethyl-4-oxotetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate 
• 104432-02-2 Benzoic acid (S)-methoxycarbonyl-((2R,4R,5R,6R)-2-methoxy-5,6-dimethyl-4-phenylselanylmethyl-tetrahydro-pyran-2-yl)-methyl ester 

Downstream Products

• 956117-45-6 (S)-2-chloro-1-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylenetetrahydro-2H-pyran-2-yl)-2-oxoethyl benzoate 
• 123483-10-3 (+)-dibenzoylpederin 
• 175085-05-9 (S)-2-(benzoyloxy)-2-((2R,5R,6R)-tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2H-pyran-2-yl)acetic acid 

Relevant articles and documents

PEDERIN AND PSYMBERIN AGENTS

Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold in

Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs

The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages.

Total synthesis of mycalamide A

This communication describes a concise and efficient total synthesis of mycalamide A by the convergent coupling of pederic acid unit with the mycalamine unit. The left-half, (+)-7-benzoylpederic acid, was synthesized from (2R,3R)-3-methylpent-4-en-2-ol in

Simple and efficient synthesis of (+)-methyl 7-benzoylpederate, a key intermediate toward the mycalamides

(equation presented) A simple and efficient method for the synthesis of (+)-methyl 7-benzoylpederate, the left half of pederin, mycalamides, onnamides, and theopederins, was developed. The key reactions include the Evans asymmetric aldol reaction, a thioa

Total synthesis of mycalamide A. Further synthetic study of the right half

The right half 5 of mycalamide A (1) was synthesized starting from (R)- or (S)-pantolactone via the Sharpless asymmetric dihydroxylation as the key step. The total synthesis of mycalamide A (1) was accomplished by coupling of the right and left halves.