175134-98-2

Basic information

• Product Name: N-(3-CYANOPHENYL)PYRROLE
• Synonyms: 3-(1H-PYRROL-1-YL)BENZONITRILE;N-(3-CYANOPHENYL)PYRROLE;3-(1-Pyrrolo)benzonitrile;3-(PYRROL-1-YL)BENZONITRILE
• CAS NO: 175134-98-2
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.19
• Mol File: 175134-98-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 306.3°Cat760mmHg
• Flash Point: 139.1°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.000776mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: N-(3-CYANOPHENYL)PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CYANOPHENYL)PYRROLE(175134-98-2)
• EPA Substance Registry System: N-(3-CYANOPHENYL)PYRROLE(175134-98-2)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 175134-98-2(Hazardous Substances Data)

Usage

General Description

N-(3-Cyanophenyl)pyrrole is a chemical compound that belongs to the class of pyrroles, which are aromatic heterocyclic compounds. It is characterized by a pyrrole ring with a cyanophenyl group attached to the nitrogen atom. N-(3-CYANOPHENYL)PYRROLE has demonstrated various biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. It has also been studied for its potential applications in organic electronics, such as in the development of organic semiconductors. Additionally, N-(3-Cyanophenyl)pyrrole has been investigated for its potential use in the synthesis of novel pharmaceuticals and other bioactive compounds. Overall, this chemical compound exhibits diverse and promising properties that make it an interesting subject of research in both the fields of chemistry and biomedicine.

InChI:InChI=1/C11H8N2/c12-9-10-4-3-5-11(8-10)13-6-1-2-7-13/h1-8H

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 2237-30-1 m-cyanoaniline 
• 6117-80-2 1,4-butenediol 
• 619-24-9 3-nitrobenzonitrile 

Downstream Products

• 1027247-32-0 4-bromo-1-(3-cyano-phenyl)-1H-pyrrole-2-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide 
• 256512-33-1 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide 
• 1026040-98-1 4-bromo-1-(3-cyano-phenyl)-1H-pyrrole-2-carboxylic acid 
• 209958-48-5 1-(3-cyanophenyl)-2-formyl-4-bromopyrrole 
• 209958-46-3 1-(3-cyanophenyl)pyrrole-2-carboxylic acid 
• 209958-45-2 1-(3-cyanophenyl)pyrrole-2-carboxaldehyde 

Relevant articles and documents

Utilization of caffeine carbon supported cobalt catalyst in the tandem synthesis of pyrroles from nitroarenes and alkenyl diols

Employing bio-waste caffeine carbon-supported heterogeneous cobalt catalyst, synthesis of various substituted pyrrole derivatives is reported. In this methodology, pyrroles were synthesized through coupling between nitroarenes and alkenyl diols in a tandem manner. Among all the heterogeneous catalysts Co(OAc)2-CC-800 displayed the highest catalytic activity. Preparative scale synthesis of pyrroles and synthesis of anti-tubercular agent 5-(4-(1H-pyrrol-1-yl)phenyl)-1,3,4-oxadiazole-2-thiol revealed the practical applicability of this protocol. Several kinetic experiments and Hammett studies were conducted to understand the probable mechanism and electronic effects on this transformation.

Lactam derivatives and preparation method and application thereof

The invention relates to lactam derivatives and a preparation method and application thereof. Compared with the prior art, the invention provides lactam compounds with a novel structure. The compoundsand compositions thereof have remarkable activity in inhibition of the proliferation of cancer cells (including, but not limited to, the liver cancer cell line HepG2 and the lung cancer cell line A549), and the activity of multiple compounds is in the same order of magnitude as the activity of the commercial drug adriamycin or superior to the activity of adriamycin. The compounds of the inventioncan be prepared from N-substituted pyrrole compounds through a reaction, and the preparation method is convenient, rapid and efficient.

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli