209958-48-5

Usage

Chemical structure

Contains a benzene ring, a nitrile group, a bromine atom, a formyl group, and a benzyl group attached to a pyrrole ring
Commonly used in organic synthesis as a building block for more complex organic molecules
Versatile molecule for various chemical reactions
Potential applications in pharmaceuticals, agrochemicals, and materials science

Upstream product

• 209958-45-2 1-(3-cyanophenyl)pyrrole-2-carboxaldehyde 
• 2237-30-1 m-cyanoaniline 
• 175134-98-2 3-(1H-pyrrol-1-yl)benzonitrile 

Downstream Products

• 1026040-98-1 4-bromo-1-(3-cyano-phenyl)-1H-pyrrole-2-carboxylic acid 
• 1027247-32-0 4-bromo-1-(3-cyano-phenyl)-1H-pyrrole-2-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide 

Relevant academic research and scientific papers

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli

Nitrogen containing heteroaromatics as factor Xa inhibitors

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.