17514-52-2

Usage

Uses

1. Used in Pharmaceutical Industry:
1-[(o-Chlorophenyl)thio]-2-propanone is used as a key intermediate for the synthesis of pharmacologically active benzo[b]thiophene derivatives, which have potential applications in the development of new drugs and therapies.
2. Used in Chemical Research:
1-[(o-Chlorophenyl)thio]-2-propanone serves as a valuable compound in chemical research, particularly in the field of organic chemistry, where it can be utilized to explore new reactions and develop novel synthetic pathways for the creation of various chemical products.

Upstream product

• 6320-03-2 2-chlorothiphenol 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 31121-19-4 bis(2-chlorobenzene)disulfide 
• 67-64-1 acetone 
• 78-95-5 chloroacetone 

Downstream Products

• 17512-61-7 3-Bromomethyl-7-chlorobenzothiophene 
• 99592-39-9 sertaconazole nitrate 
• 17514-68-0 3-methyl-7-chlorobenzo[b]thiophene 

Relevant academic research and scientific papers

Preparation process of sertaconazole nitrate

The invention provides a preparation process of sertaconazole nitrate. The preparation process comprises the following steps: acylating, cyclizing, brominating, salifying and refining to obtain the finished product of sertaconazole nitrate. By adopting the preparation process of sertaconazole nitrate, the obtained finished product of sertaconazole nitrate is high in purity and high in yield. By adopting the preparation process of the sertaconazole nitrate, the raw materials are fully reacted, the generation of impurities is effectively reduced, the purity of a crude product is greatly improved, finally, the finished product of the sertaconazole nitrate obtained by adopting a refining process is high in purity and yield, and the production benefit of a sertaconazole nitrate bulk drug is effectively improved.

Synthesis of α-arylthioacetones using TEMPO as the: C 3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C-S bond formation

Here, we present an unprecedented pathway to α-sulfenylated carbonyl compounds from commercially available thiols and universally employed TEMPO and its analogues, which act as C3 synthons through skeletal rearrangement under simple and metal-f

α-Arylchalcogenation of acetone with diaryl dichalcogenide via metal-free oxidative C(sp3)-H bond functionalization

Direct α-arylchalcogenation of acetone with diaryl dichalcogenides has been achieved by using a mixture of TBHP and DTBP oxidants at 120 °C without transition-metal catalyst via oxidative C(sp3)-H bond functionalization. The method exhibits good functional group tolerance and products were isolated in moderate to high yields.

NEW COMPOUNDS

A compound of formula (I), wherein A is S, O or a double bond, and L is a substituted thiazolyl, phenyl or pyridyl. The compound is useful for the treatment of inflammation and cancer.

BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER

A compound of formula (I). The compound is useful for treating cancer and inflammatory diseases. A pharmaceutical composition containing the compound.