17515-80-9

Usage

Uses

Used in Pharmaceutical Industry:
5-(TRIFLUOROMETHYL)-2-FURALDEHYDE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs, enhancing their efficacy and therapeutic potential.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(TRIFLUOROMETHYL)-2-FURALDEHYDE is utilized as a chemical intermediate in the production of agrochemicals. Its properties contribute to the effectiveness of these products, supporting agricultural practices and crop protection.
Used as a Flavor Additive in Food Industry:
5-(TRIFLUOROMETHYL)-2-FURALDEHYDE is employed as a flavor additive in food products, capitalizing on its fruity aroma to enhance the sensory experience of consumers. Its use in food formulations adds depth and complexity to the taste profiles of various edible items.

InChI:InChI=1/C14H13BrO/c1-11-9-13(7-8-14(11)15)16-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3

Upstream product

• 901766-98-1 Trifluoro-acetic acid furan-2-yl-(2,2,2-trifluoro-acetoxy)-methyl ester 
• 76-05-1 trifluoroacetic acid 
• 65865-28-3 (5-(trifluoromethyl)furan-2-yl)methanol 
• 56286-73-8 5-(trifluoromethyl)furan-2-carboxylic acid 
• 98-01-1 furfural 

Downstream Products

• 1314872-83-7 7,9-dimethyl-11-phenyl-6-(5-trifluoromethylfuran-2-yl)-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione 
• 936234-79-6 [(3S)-3-(N-benzyloxycarbonyl)amino-3-methoxycarbonylpropyl][(5-trifluoromethylfuran-2-yl)hydroxymethyl]phosphinic acid 
• 1383427-93-7 C₁₄H₂₂F₃NO₂Si 
• 71160-09-3 2,6-dimethyl-4-(5-trifluoromethyl-furan-2-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of trifluoromethyl-substituted heteroaromatic aldehydes

Trifluoromethylation of furfural and thiophene-2-carbaldehyde trifluoroacetates with XeF2 and CF3COOH afforded 5-trifluoromethylfuran-2-carbaldehyde and 5-trifluoromethylthiophene-2- carbaldehyde.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.