175205-54-6

Basic information

• Product Name: 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE
• Synonyms: 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENE-1-SULFONYL CHLORIDE;2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE;2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULPHONYL CHLORIDE;BUTTPARK 27\06-37;2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULF&;2-Chloro-4-(trifluoromethyl)benzenesulphonyl chloride 97%;2-Chloro-4-(trifluoromethyl)benzenesulphonylchloride97%;2-Chloro-4-(trifluoromethyl)benzenesulfonyl
• CAS NO: 175205-54-6
• Molecular Formula: C₇H₃Cl₂F₃O₂S
• Molecular Weight: 279.06
• Product Categories: Benzenesulfonyl chloride;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 175205-54-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 37-39°C
• Boiling Point: 70-71 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.597 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00819mmHg at 25°C
• Refractive Index: n20/D 1.5080(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE(175205-54-6)
• EPA Substance Registry System: 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE(175205-54-6)

Safety Data

• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 175205-54-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride is a highly reactive and corrosive chemical compound with the formula C7H4Cl2F3O2S. It is a sulfonyl chloride derivative with a chlorine atom and a trifluoromethyl group attached to a benzene ring, making it a versatile building block for the synthesis of various pharmaceuticals and agrochemicals. 2-CHLORO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE is widely used in organic synthesis as a sulfonylating agent, as well as in the production of dyes, polymers, and other industrial chemicals. It is important to handle this substance with caution due to its toxic and irritating nature, and appropriate safety measures should be taken when working with it.

InChI:InChI=1/C7H3Cl2F3O2S/c8-5-3-4(7(10,11)12)1-2-6(5)15(9,13)14/h1-3H

Upstream product

• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 

Downstream Products

• 675866-07-6 2-chloro-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[4-(tetrahydro-pyran-2-yloxy)-benzyl]-4-trifluoromethyl-benzenesulfonamide 
• 315223-20-2 2-Chloro-N-[3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-4-trifluoromethyl-benzenesulfonamide 
• 315225-00-4 N-[3-Acetyl-5-chloro4-(5-chloro-benzothiazol-2-ylsulfanyl)-phenyl ]-2-chloro-4-trifluoromethyl-benzenesulfonamide 
• 1350150-90-1 C₂₄H₁₉Cl₂F₃N₂O₆S 
• 1240315-06-3 1-(1-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-3-piperidinyl)-2-pyrrolidinone 
• 315224-25-0 C₂₂H₁₂Cl₃F₃N₂O₃S 

Relevant articles and documents

Preparation method of halogenated aromatic sulfonyl chloride

The invention discloses a preparation method of halogenated aromatic sulfonyl chloride. The preparation method specifically comprises the following steps of: 1, preparing a SO2 water saturated solution; 2, preparing a heavy ammonium salt; and 3, preparing sulfonyl chloride, finally desolventizing the filtrate at 30-38 DEG C under reduced pressure by using a water pump until no liquid is discharged to obtain 6.0 g of brownish red liquid, controlling the purity to be 93.2% by using HPLC (High Performance Liquid Chromatography), and standing overnight to obtain a solid on the second day. The thionyl chloride used in the method is used as a raw material, the method is economical, cheap and easy to operate, the whole reaction process is safe and stable, the reaction efficiency is high, the pure product rate of the obtained product is high, and industrial large-scale production is easy.

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.