175205-85-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-dibromobenzamide is used as a key intermediate in the production of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-dibromobenzamide is utilized as an intermediate, playing a crucial role in the synthesis of compounds that can enhance crop protection and management.
Used in Dye and Pigment Manufacturing:
3,5-dibromobenzamide is employed as an intermediate in the creation of dyes and pigments, contributing to the coloration and stability of various products in different industries.
Environmental Considerations:
3,5-dibromobenzamide has been identified as a potential environmental contaminant, which may pose risks to aquatic organisms. Therefore, it is imperative to handle 3,5-dibromobenzamide with care and ensure proper disposal methods to mitigate any harmful effects on the environment.

InChI:InChI=1/C7H5Br2NO/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3H,(H2,10,11)

Upstream product

• 23950-59-6 3,5-dibromobenzoyl chloride 
• 4123-72-2 4-amino-3,5-dibromobenzoic acid 
• 145691-59-4 (3,5-dibromophenyl)methanol 
• 59785-43-2 3,5-dibromo-1-ethylbenzene 
• 618-58-6 3,5-dibromobenzoic acid 

Downstream Products

• 1631160-91-2 3,5-bis[2-[3,4,5-tris(octyloxy)phenyl]ethynyl]phenyltetrazole 
• 1395084-11-3 5-(3,5-dibromophenyl)-2H-tetrazole 
• 97165-77-0 3,5-dibromobenzonitrile 
• 1312924-00-7 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-bromobenzonitrile 
• 686768-53-6 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromobenzonitrile 

Relevant academic research and scientific papers

Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.

Direct Transformation of Ethylarenes into Primary Aromatic Amides with N -Bromosuccinimide and I2-Aqueous NH3

A variety of ethylarenes were converted into the corresponding primary aromatic amides in good yields via treatment with N-bromosuccinimide in the presence of a catalytic amount of 2,2′-azobis(isobutyronitrile) in a mixture of ethyl acetate and water, acetonitrile and water, or chloroform and water, followed by reaction with molecular iodine and aq NH3 in one pot. It was found that aryl α-bromomethyl ketones and/or aryl methyl ketones were formed at the first reaction step and their iodoform-type reaction occurred at the second reaction step to provide primary aromatic amides. The present reaction is a useful and practical transition-metal-free method for the preparation of primary aromatic amides from ethylarenes. (Chemical Equation Presented).

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.