Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of Conjugated Allenyl Esters as the Latent Active Species: A New Approach to the Development of Cysteine Proteinase Inhibitors

Article abstract of DOI:10.1016/0040-4039(95)02284-8

Various diethyl α-alkynylmalonates (DAM) having potential as cysteine proteinase inhibitors were synthesized by treatment of diethyl acetyliminomalonate (or ketomalonate) with several lithium acetylides. Hydrolytic decarboxylation of the DAM under the mil