Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of Conjugated Allenyl Esters as the Latent Active Species: A New Approach to the Development of Cysteine Proteinase Inhibitors

DOI: 10.1016/0040-4039(95)02284-8

Source and publish data:

Tetrahedron Letters p. 861 - 864 (1996)

Update date:2022-08-04

Topics:

Authors:

Nagao, Yoshimitsu

Kim, Kweon

Sano, Shigeki

Kakegawa, Hisao

Lee, Woo Song

Shimizu, Hisashi

Shiro, Motoo

Katunuma, Nobuhiko

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Article abstract of DOI:10.1016/0040-4039(95)02284-8

Various diethyl α-alkynylmalonates (DAM) having potential as cysteine proteinase inhibitors were synthesized by treatment of diethyl acetyliminomalonate (or ketomalonate) with several lithium acetylides. Hydrolytic decarboxylation of the DAM under the mil

Full text of DOI:10.1016/0040-4039(95)02284-8

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