1375413-67-4Relevant academic research and scientific papers
Photocaged permeability: A new strategy for controlled drug release
Dcona, M. Michael,Mitra, Deboleena,Goehe, Rachel W.,Gewirtz, David A.,Lebman, Deborah A.,Hartman, Matthew C. T.
, p. 4755 - 4757 (2012)
Light is used to release a drug from a cell impermeable small molecule, uncloaking its cytotoxic effect on cancer cells.
PEG-PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy
Panda, Snigdharani,Bhol, Chandra Sekhar,Bhutia, Sujit Kumar,Mohapatra, Sasmita
, p. 3666 - 3676 (2021/05/17)
A novel hybrid drug carrier has been designed, taking N-doped mesoporous carbon (NMCS) as the core and PEG-PEI as the outer shell. NMCS was functionalized with a photocleavable nitrobenzyl-based linker following a click reaction. Gemcitabine was loaded in
COMPOUNDS AND METHODS FOR DETECTION AND ISOLATION OF BIOMOLECULES
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Paragraph 0121, (2017/05/11)
A compound of general formula R1-L1-PCL-L2-R2 is disclosed wherein PCL is a photolabile group; R1 is a reactive moiety capable of modifying biomolecules without activation; L1 is a non-clea
LIGHT-ENABLED DRUG DELIVERY
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Page/Page column 0099; 0100; 0101, (2014/09/03)
Conjugates are provided which comprise a membrane permeable drug linked to a moiety that is not membrane permeable. Attachment of the moiety that is not membrane permeable prevents the drug from crossing cell membranes and entering cells. However, exposure to light either i) breaks the linkage, releasing the drug and allowing it to enter cells; or ii) converts the non-membrane permeable moiety to a membrane permeable form, allowing the entire conjugate to enter the cell, where the drug is released from the conjugate by cleavage. The membrane permeable drugs are thus delivered to cells at locations of interest, e.g. cancer cells in a tumor, in a temporally and spatially controlled manner.
