175287-55-5Relevant academic research and scientific papers
Synthesis of Enantiomerically Pure Threo 1-Alkyl-2-benzyloxy-propylamines
Solladie-Cavallo, Arlette,Bonne, Frederique
, p. 171 - 180 (2007/10/03)
Pure (1S,2S)-1-Butyl- and (1S,2S)-1-isobutyl-2-benzyloxy-propylamine have been synthesized in 5 steps and 62% overall yield from (S)-ethyl lactate. It was found that BuLi and i-BuMgBr add readily and diastereoselectivety (d.e.> 96 %) to α-benzyloxypropionaldehyde dimethylhydrazone and that hydrogenolysis proceeds in high yield and without epimerization.
