175409-50-4

Upstream product

• 50424-93-6 3-methyl-2-nitrobenzoyl chloride 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 67-56-1 methanol 
• 100230-78-2 (2S)-N-(3-methyl-2-nitrobenzoyl)proline 

Downstream Products

• 176387-48-7 (S)-1-(3-Methyl-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde 
• 175521-33-2 (S)-1-(3-Methyl-2-nitro-benzoyl)-pyrrolidine-2-carbaldehyde 

Relevant academic research and scientific papers

A new route for the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via oxidation of cycle secondary amine

The synthesis of the imine-containing pyrrolo[2,1-c][1,4]benzodiazepine DNA-binding antitumour antibiotics was achieved by a new method of oxidation of cyclic secondary amines which does not endanger the stereochemical integrity of the C-11a position.

A new facile procedure for the preparation of pyrrolo[2,1-c][1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

An efficient synthesis of the imine form of the pyrrolo[2,1-c][1,4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81(5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.