175410-79-4

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 141-78-6 ethyl acetate 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 175410-69-2 ethyl dl-5-phenyl-3-(2-tetrahydropyranyloxy)-4-pentynoate 
• 175410-80-7 5-Phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-4-yn-1-ol 
• 41415-69-4 (dl)-2-(2-phenylethynyl)oxetane 
• 175410-70-5 dl-1-phenyl-5-(p-toluenesulfonyloxy)-1-pentyn-3-ol 
• 175410-81-8 Toluene-4-sulfonic acid 5-phenyl-3-(tetrahydro-pyran-2-yloxy)-pent-4-ynyl ester 
• 1008475-03-3 ethyl 3-[diethyl-(3'-trimethylsilanylprop-1'-ynyl)silanyloxy]-5-phenyl-pent-4-ynoate 
• 1421773-38-7 rac-(Z)-ethyl 3-hydroxy-5-phenylpent-4-enoate 
• 91344-76-2 3-hydroxy-5-phenylpent-4-ynoic acid 

Relevant academic research and scientific papers

Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

The first successful example of the direct synthesis of Weinreb amides using catalytic hydroxy-directed dehydrative amidation of carboxylic acids using the diboronic acid anhydride catalyst is described. The methodology is applicable to the concise syntheses of eight α-hydroxyketone natural products, namely, sattabacin, 4-hydroxy sattabacin, kurasoins A and B, soraphinols A and B, and circumcins B and C.

Utilization of whole cell mediated deracemization in a chemoenzymatic synthesis of enantiomerically enriched polycyclic chromeno[4,3-b] pyrrolidines

Various aryl and alkyl substituted optically pure propargyl alcohols were obtained with excellent ee (up to >99%) and isolated yields (up to 87%) by deracemization using whole cells of Candida parapsilosis ATCC 7330. The whole cells show substrate specificity towards alkyl substituted propargyl alcohols and a switch in the enantioselectivity has been observed from 'R' to 'S' upon increasing the chain length. For the first time, enantiopure (R)-4-(3-hydroxybut-1-ynyl)benzonitrile, (R)-4-(biphenyl-4-yl)but-3-yn-2-ol, (S)-ethyl 3-hydroxy-5-phenylpent-4-ynoate and (S)-4-phenylbut-3-yne-1,2-diol were obtained using this strategy. Optically pure propargyl alcohol thus obtained was used as a chiral starting material in the synthesis of enantiomerically enriched poly-substituted pyrrolidines and a pyrrole derivative successfully demonstrating a chemoenzymatic route. This journal is

A Bronsted acid mediated cascade enone synthesis from aldehydes containing a tethered propargylsilane

(Chemical Equation Presented) MeSO3H effects the intramolecular allenylation of a series of aldehydes 1 to provide allenyl alcohol product 3 as a single diastereoisomer. Cyclization proceeds rapidly at -78°C. However, when the reaction is perfo

Synthesis of alkylidenecyclopentenones and dialkylidenecyclopentenones via the coupling of propargylic alcohol and 2-alkyne-1,4-diol derivatives with cyclopropylcarbene-chromium complexes

The coupling of propargylic alcohols and their derivatives with cyclopropylcarbene-chromium complexes has been investigated. The coupling reaction leads to alkylidenecyclopentenones or alkoxyalkyl-cyclopentenones, depending on the leaving group ability of

Synthesis of alkylidenecyclopentenones via the coupling of propargyl alcohol derivatives with cyclopropylcarbene-chromium complexes

(equatio presented) The coupling of propargylic alcohols and their derivatives with cyclopropylcarbene-chromium complexes has been investigated. The coupling reaction leads to alkylidenecyclopentenones or alkoxyalkylcyclopentenones, depending on the leavi

Chiral bipyrindine and biquinoline ligands: Their asymmetric synthesis and application to the synthesis of trans-whisky lactone

Chiral bipyrindine and biquinoline which have been reported to be efficient ligands for the construction of chiral copper catalysts, were synthesized enantioselectively by using Mn-salen catalyzed asymmetric epoxidation as a key step. Enantioselective synthesis of trans-whisky lactone was then achieved by way of enantiospecific ring expansion reaction of oxetane with a chiral copper catalysts bearing the bipyrindine ligand as a chiral source.