175601-07-7

Upstream product

• 101119-50-0 1,1-dianisyl-2,2,2-trichloroethyl chloride 
• 50-89-5 thymidine 

Downstream Products

• 164798-90-7 5'-O-(1,1-dianisyl-2,2,2-trichloroethyl)-3'-O-(N,N-dimethylaminotrifluoromethylphosphine) thymidine 
• 175601-08-8 5'-O-(1,1-dianisyl-2,2,2-trichloroethyl)-3'-O-(N,N-diethylaminotrifluoromethylphosphine) thymidine 

Relevant academic research and scientific papers

The 1,1-dianisyl-2,2,2-trichloroethyl moiety as a new protective group for the synthesis of dinucleoside trifluoromethylphosphonates

The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5'-O-DATE-thymidine and 3'-O-acetylthymidine are phosphorylated with CF3P(NR2)2 to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate.