The 1,1-dianisyl-2,2,2-trichloroethyl moiety as a new protective group for the synthesis of dinucleoside trifluoromethylphosphonates

Article abstract of DOI:10.1080/07328319608002391

The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5'-O-DATE-thymidine and 3'-O-acetylthymidine are phosphorylated with CF₃P(NR₂)₂ to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate.

Full text of DOI:10.1080/07328319608002391

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Nucleosides and Nucleotides
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The 1,1-Dianisyl-2,2,2-trichloroethyl
Moiety as a New Protective Group
for the Synthesis of Dinucleostde
Trifluoromethylphosphonates
Rosa Maria Karl a , Wolfgang Richter a , Roland Klösel b , Michael
Mayer b & Ivar Ugi b
a Institut für Physiologische Chemie, Technische Universitat
München , Biedersteinerstraße 29, D-80802, München, Germany
b Institut für Organische Chemie und Biochemie, Technische
Universität München , Lichtenbergstraße 4, D-85747, Garching,
Germany
Published online: 21 Aug 2006.
To cite this article: Rosa Maria Karl , Wolfgang Richter , Roland Klösel , Michael Mayer & Ivar Ugi
(1996) The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of
Dinucleostde Trifluoromethylphosphonates, Nucleosides and Nucleotides, 15:1-3, 379-386
To link to this article: http://dx.doi.org/10.1080/07328319608002391
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