164798-90-7

Upstream product

• 3135-63-5 Chlor--trifluormethyl-phosphin 
• 175601-07-7 5'-O-(1,1-dianisyl-2,2,2-trichloroethyl) thymidine 
• 3205-96-7 Bis---phosphin 
• 50-89-5 thymidine 
• 101119-50-0 1,1-dianisyl-2,2,2-trichloroethyl chloride 

Relevant academic research and scientific papers

STUDIES ON TRIFLUOROMETHYLPHOSPHONAMIDITE ANALOGUES AS BUILDING BLOCKS IN OLIGONUCLEOTIDE SYNTHESIS

The phosphorylating reagents CF3P(NMe2)Cl and CF3P(NEt2)Cl are used to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites.Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.

The 1,1-dianisyl-2,2,2-trichloroethyl moiety as a new protective group for the synthesis of dinucleoside trifluoromethylphosphonates

The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5'-O-DATE-thymidine and 3'-O-acetylthymidine are phosphorylated with CF3P(NR2)2 to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate.