17565-23-0

Upstream product

• 1618-26-4 2,4-dithiapentane 
• 611-74-5 N,N-dimethylbenzamide 
• 5188-07-8 sodium thiomethoxide 
• 93-97-0 benzoic acid anhydride 
• 5418-86-0 tris(methylthio)methane 
• 98-88-4 benzoyl chloride 
• 1484-17-9 S-ethyl thiobenzoate 
• 5925-68-8 (S)-methyl thiobenzoate 
• 21504-18-7 2,2,2-Tris-methylsulfanyl-1-phenyl-ethanone 
• 93-58-3 benzoic acid methyl ester 
• 6156-25-8 tetrathioorthocarbonic acid tetramethyl ester 
• 624-92-0 Dimethyldisulphide 
• 70-11-1 α-bromoacetophenone 
• 66739-97-7 methyl 2-oxo-2-phenylethanedithioate 

Downstream Products

• 21504-15-4 1-Phenyl-2,2-(dimethylsulfanyl)vinyl benzoate 
• 21504-16-5 β,β-Di-(methylmercapto)-α-acetoxystyrol 
• 70719-06-1 1,2-Dibenzoyl-1,1,2,2-tetra-(methylmercapto)-aethan 
• 21517-43-1 2,3-Bis(methylthio)-1,4-diphenyl-2-buten-1,4-dion 

Relevant academic research and scientific papers

Rhodium-catalyzed α-methylthiolation reaction of unactivated ketones using 1,2-diphenyl-2-methylthio-1-ethanone for the methylthio transfer reagent

In the presence of catalytic amounts of RhH(PPh3)4, 1,2-bis(diphenylphosphino)ethane (dppe), and dimethyl disulfide, ketones without α-activating groups were α-methylthiolated with 1,2-diphenyl-2-methylthio-1-ethanone giving α-methylthio ketones. The reaction of unsymmetrical ketones proceeded at the more substituted carbons. The initial formation of kinetic α-methylthiolated products followed by their rearrangement to thermodynamic products was observed in the reaction of α-phenyl ketones. Aldehydes, phenylacetate, and phenylacetonitrile were also α-methylthiolated under these conditions.

An activated catalyst RhH(PPh3)4-dppe-Me 2S2 for α-methylthiolaton of α-phenyl ketones

In the presence of catalytic amounts of RhH(PPh3)4, 1,2-bis(diphenylphosphino)ethane (dppe), and dimethyl disulfide, cyclic and acyclic α-phenyl ketones reacted with p-cyano-α- methylthioacetophenone giving α-methylthio-α-phenylketones. The activated catalyst containing dimethyl disulfide was effective for the α-methylthiolation reaction of these less reactive substrates.

Synthesis of Trimethyl α-Keto Trithioorthoesters and Dimethyl α-Keto Dithioacetals by Reaction of Esters with Tris(methylthio)methyllithium

A complete study has been made of the reaction of tris(methylthio)methyllithium with aromatic, heteroaromatic, and aliphatic esters.It is a one-pot reaction that despite its complexity, and depending on the reagent ratios, the reaction conditions, and the possible use of additional reagents (N-(methylthio)phthalimide or BuLi), can supply easily, in excellent and reproducible yields, the trimethyl α-keto trithioorthoesters 3 or, alternatively, the dimethyl α-keto dithioacetals 4.The reaction mechanism has been elucidated.

Sodium Telluride-Mediated Sulfenylation of α-Halo Carbonyl Compounds with Diphenyl Disulfide

Under mild aprotic conditions α-halo carbonyl compounds react with diphenyl disulfide in the presence of sodium telluride to give the corresponding α-phenylthio derivatives in good to moderate yields.The reaction appears to proceed involving the sulfur-sulfur bond cleavage of diphenyl disulfide by sodium telluride.

Electroreduction of Organic Compounds, 9. - Convenient Electrochemical Preparation of Thioacetals from Dithioesters

Thioacetals are obtained as main products on electroreduction of alkyl dithiocarboxylates of various types in the presence of dimethyl sulfate in methanol. (Z)- and (E)-1,2-diaryl-1,2-bis(methylthio)ethenes are formed as byproducts.No reduction to form be