1758-77-6

Basic information

• Product Name: L-2-aziridinecarboxylic acid
• Synonyms: L-2-aziridinecarboxylic acid;(S)-Aziridine-2-carboxylic acid
• CAS NO: 1758-77-6
• Molecular Formula: C₃H₅NO₂
• Molecular Weight: 87.0773
• Mol File: 1758-77-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: L-2-aziridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-aziridinecarboxylic acid(1758-77-6)
• EPA Substance Registry System: L-2-aziridinecarboxylic acid(1758-77-6)

Safety Data

• Hazardous Substances Data: 1758-77-6(Hazardous Substances Data)

Usage

General Description

L-2-aziridinecarboxylic acid is a chemical compound that belongs to the class of aziridine carboxylic acids. It is a heterocyclic compound consisting of a three-membered ring containing one nitrogen atom and two carbon atoms. L-2-aziridinecarboxylic acid is an important building block in the synthesis of various pharmaceuticals and agrochemicals. L-2-aziridinecarboxylic acid is known for its potential applications in the development of new drugs and is also used as a chiral auxiliary in asymmetric synthesis. It exhibits unique reactivity due to the presence of the aziridine functional group, making it a valuable intermediate in organic synthesis. Additionally, it has been studied for its potential anticancer and antimicrobial properties, making it an important compound in chemical research and drug development.

Upstream product

• 1286768-92-0 (S)-2-Boc-aziridine-2-carboxylic acid 
• 2731-73-9 (S)-3-chloroalanine 
• 112346-82-4 D-β-Chloroalanine methyl ester hydrochloride 

Downstream Products

• 114502-00-0 (2S)-2-amino-3-<(2-amino-1-carboxyethyl)-thio>propanoic acid 
• 922-55-4 lanthionine 
• 114501-98-3 3-Amino-2-((R)-2-amino-2-carboxy-ethylsulfanyl)-propionic acid 
• 733035-13-7 L,L-Lanthionine 
• 356519-34-1 (2S)-1-(2-nitrobenzene-1-sulfonyl) aziridine-2-carboxylic acid 

Relevant articles and documents

Polybasic nitrogen heterocyclic non-natural chiral amino acid and synthesis method thereof

The invention relates to a polybasic nitrogen heterocyclic non-natural chiral amino acid and a synthesis method thereof. The amino acid can be applied to molecule building for antibiotic synthesis. According to the synthesis method, 2-aminodiethyl malonate and halogenated alkanes carry out substitution reactions, cyclization reactions, and decarboxylation reactions, and the reaction products are split to obtain the polybasic nitrogen heterocyclic non-natural chiral amino acid. The provided novel synthesis method has the advantages of simple synthesis route, low cost, convenient operation, andeasiness for commercial production, the chiral purity of obtained products is high, and the application prospect is good.

PROCESSES FOR PREPARING OPTICALLY ACTIVE AMINO ACID DERIVATIVES

An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.