17583-14-1

Upstream product

• 932-23-0 2-chloro-cyclohexane-1,3-dione 
• 62-55-5 thioacetamide 
• 60060-44-8 2-bromocyclohexane-1,3-dienone 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 33708-23-5 4,6-(Z,E)-dibenzylidene-2-methyl-5,6-dihydro-4H-benzothiazol-7-one 
• 14366-03-1 2-methyl-6-phenyl-4,5-dihydro-thiazolo[4,5-c]acridine 
• 33082-03-0 2-methyl-4,5,6,7-tetrahydro-benzothiazole 
• 827598-56-1 2-methyl-7-oxo-4,5,6,7-tetrahydro-benzothiazole-6-carbaldehyde 
• 1312412-60-4 (E)-2-styryl-5,6-dihydrobenzo[d]thiazol-7(4H)-one 

Relevant academic research and scientific papers

Versatile approaches to a library of building blocks based on 5-acylthiazole skeleton

Thiazole derivatives represent an important class of azole heterocycles with a broad spectrum of biological activity and, therefore, the synthesis of these compounds is of remarkable concern. We present here practical and reliable protocol for synthesis of some 5-acylthiazoles and demonstrate their utility in the preparation of several new series of thiazole-containing building blocks through transformation of 5-acyl function. Specifically, thiazole-based alcohols, oximes, primary, and secondary amines were successively synthesized in good to excellent yields. The chemical structures of obtained compounds were confirmed by 1H and 13C NMR-spectroscopy, elemental analysis, and mass-spectrometry.

Carboxamide benzothiazole - 7 - oxime pharmaceutical, preparation method and application thereof

The invention relates to a tetrahydrobenzothiazole-7-ketoxime medicine. The structural formula of tetrahydrobenzothiazole-7-ketoxime medicine comprises a cis-isomer and a trans-isomer (shown in the specification). The tetrahydrobenzothiazole-7-ketoxime me

TMSCl Promoted Direct sp3 C-H Alkenylation to Construct (E)-2-Styryl-tetrahydrobenzo[d]thiazoles

A high-efficient and stereo-specific approach for the preparation of biologically important (E)-2-styryl-tetrahydrobenzo[d]thiazoles has been developed via TMSCl promoted direct sp3 C-H alkenylation of 2-methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-

TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5- dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors

Following the recent discovery and development of 2-anilino-4-(thiazol-5- yl)pyrimidine cyclin dependent kinase (CDK) inhibitors, a program was initiated to evaluate related ring-constrained analogues, specifically, 2-methyl- and 2-amino-N-aryl-4,5-dihydr

THIAZOLES AS FUNGICIDES

Use of compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and X, Y, Z are as defined in the description as fungicides. Compounds of the formula (Ia)

A New Heteroannulation Method to 2-Cyclohexenone, Mediated by Phosphonate Auxiliaries. Synthesis of 4,5,6,7-Tetrahydrobenzothiazole Derivatives

Dimethyl (1,2-epoxy-3-oxocyclohex-1-yl)phosphonate 7, easily available from 2-cyclohexen-1-one, affords the new (tetrahydrobenzothiazolyl)phosphonates 10 upon reaction with thiocarboxamides 8.This cyclocondensation proceeds with regioselective conjunction

Synthesis of aminoderivatives of 4,5,6,7-tetrahydro-benzothiazole. I. 4,5,6- and 7-amino and N-methyl amino derivatives with central dopaminergic activity

4-Oxo and 6-oxo-4,5,6,7-tetrahydro-benzothiazoles were prepared from diester derivatives of thiazole through Dieckmann cyclisation. The 7-oxo compound was synthesized by formation of a thiazole ring on 2-bromo-1,3-cyclohexanedione. The ketones were tranformed into amines and N-methylamines by reductive amination. The 5-amino derivatives were obtained by Hofmann reaction of the corresponding amides. The amines and N-methylamines in the 6-position have central dopaminergic properties. Their isomers in the 4, 5 or 7 positions are inactive.