175850-45-0Relevant academic research and scientific papers
Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus
Schroeder, Chad E.,Yao, Tuanli,Sotsky, Julie,Smith, Robert A.,Roy, Sudeshna,Chu, Yong-Kyu,Guo, Haixun,Tower, Nichole A.,Noah, James W.,McKellip, Sara,Sosa, Melinda,Rasmussen, Lynn,Smith, Layton H.,White, E. Lucile,Aubé, Jeffrey,Jonsson, Colleen B.,Chung, Donghoon,Golden, Jennifer E.
, p. 8608 - 8621 (2014/12/11)
Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort wa
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors
Huang, Wenwei,Huang, Ruili,Attene-Ramos, Matias S.,Sakamuru, Srilatha,Englund, Erika E.,Inglese, James,Austin, Christopher P.,Xia, Menghang
supporting information; experimental part, p. 5239 - 5243 (2011/10/02)
Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthes
