175918-47-5Relevant academic research and scientific papers
Myxochelin-Inspired 5-Lipoxygenase Inhibitors: Synthesis and Biological Evaluation
Schieferdecker, Sebastian,K?nig, Stefanie,Pace, Simona,Werz, Oliver,Nett, Markus
, p. 23 - 27 (2017/01/17)
A total of 48 analogues of the natural product myxochelin A were prepared and evaluated for their inhibitory effects on human 5-lipoxygenase in both cell-free and cell-based assays. Structure–activity relationship analysis revealed that the secondary alcohol function and only chiral center of myxochelin A is not required for biological activity. By expanding the diaminoalkane linker of the two aromatic residues it was possible to generate a myxochelin derivative with superior activity against 5-lipoxygenase in intact cells.
Sequestering agent for uranyl chelation: a new family of CAMS ligands
Leydier, Antoine,Lecerclé, Delphine,Pellet-Rostaing, Stéphane,Favre-Reguillon, Alain,Taran, Frédéric,Lemaire, Marc
, p. 6662 - 6669 (2008/12/20)
The synthesis of new dipodal bis-sulfocatecholamide uranophiles is presented. Their binding abilities for uranyl cation were determined by UV spectrophotometry in aqueous media under various pH conditions and further studied by 1H NMR analysis of the resonance signal of both aromatic protons of the sulfocatecholamide groups. The results showed that the efficiency of these hydrosoluble chelating agents depends on the nature of the spacers. Each ligand shows a more or less pronounced affinity for uranium. The best receptor is the ligand CYCAMS 5d obtained as a mixture of cis/trans isomers, which achieves the best compromise between rigidity and steric hindrance.
High yield selective acylation of polyamines: Proton as protecting group
Oganesyan, Asmik,Cruz, Iris A.,Amador, Roberto B.,Sorto, Nohemy A.,Lozano, Jose,Godinez, Carlos E.,Anguiano, Jaime,Pace, Heather,Sabih, Ghiwa,Gutierrez, Carlos G.
, p. 4967 - 4970 (2008/03/28)
An advance in the selective acylation of polyamines having identical or similar amine functions is reported. While nucleophilicity differences between the various amine functions are slight, the corresponding conjugate acids exhibit pKa values
