1476-39-7

Usage

Uses

Used in Biotechnology and Microbiology:
1,5-DIAMINOPENTANE DIHYDROCHLORIDE is used as a test compound for evaluating the tolerance of Escherichia coli K12 wild-type strain W3110 for cadaverine in chemically defined R/2 medium. This application helps in understanding the adaptability and resilience of the bacterial strain in the presence of cadaverine, which can be crucial for biotechnological applications.
Used in Protein Crystallization:
In the field of biochemistry and structural biology, 1,5-DIAMINOPENTANE DIHYDROCHLORIDE is used for the crystallization of maltose-binding protein (MBP)-parathyroid hormone receptor (PTH1R) extracellular domain (ECD)-His6 fusion protein. The crystallization process is essential for determining the three-dimensional structure of proteins, which aids in understanding their function and designing targeted therapies.
Used in Chromatographic Analysis:
1,5-DIAMINOPENTANE DIHYDROCHLORIDE serves as a standard compound for the chromatographic quantification of biogenic amines in fish tissue samples. This application is vital for ensuring the accuracy and reliability of analytical results, which can be used to assess the quality and safety of fish products for consumption.
Used in Pharmaceutical Research:
Although not explicitly mentioned in the provided materials, 1,5-DIAMINOPENTANE DIHYDROCHLORIDE may also have potential applications in the pharmaceutical industry. Its ability to form crystalline structures and interact with proteins could make it a valuable compound for the development of new drugs or drug delivery systems. Further research and development in this area could lead to novel therapeutic applications for 1,5-DIAMINOPENTANE DIHYDROCHLORIDE.

InChI:InChI=1/C5H14N2.ClH/c6-4-2-1-3-5-7;/h1-7H2;1H

Upstream product

• 65898-76-2 N,N,N',N'-Tetrakis(trimethylsilyl)-1,5-pentandiamin 
• 111-24-0 1,5-dibromo-pentane 
• 657-27-2 L-Lysine hydrochloride 
• 56-87-1 L-lysine 
• 657-26-1 L-lysine dihydrochloride 
• 17607-21-5 1,5-diazidopentane 
• 462-94-2 1,5-diaminopentane 

Downstream Products

• 30800-90-9 1-phenyl-2-(piperidin-2-yl)ethan-1-one 
• 89140-08-9 3-(3'-aminopropyl)quinoline dipicrate 
• 14483-24-0 2,3-tetramethylene-1,2-dihydroquinazolinium picrate 
• 81852-10-0 N,N'-bis-p-nitrobenzoylcadverine 
• 550-43-6 (+)-angustifoline 
• 486-87-3 (+)-lupanine (6R,7S,9S,11S) 
• 6870-60-6 (+)-13α-hydroxylupanine 
• 90-39-1 (-)-l-sparteine 
• 486-70-4 lupinine 
• 69747-36-0 (5-aminopentyl)carbamic acid benzyl ester 
• 177906-33-1 [(S)-1-(5-{3-[(3-Azido-propyl)-benzyloxycarbonyl-amino]-propionylamino}-pentylcarbamoyl)-2-carbamoyl-ethyl]-carbamic acid tert-butyl ester 
• 177906-34-2 {2-[5-((S)-2-Amino-3-carbamoyl-propionylamino)-pentylcarbamoyl]-ethyl}-(3-azido-propyl)-carbamic acid benzyl ester 
• 175918-47-5 N,N'-di(2,3-dimethoxybenzoyl)-pentane-1,5-diamine 
• 31991-79-4 N,N'-pentane-1,5-diyldibenzamide 

Relevant academic research and scientific papers

Renewable Self-Blowing Non-Isocyanate Polyurethane Foams from Lysine and Sorbitol

Copolymerisation of a sorbitol-derived bis-carbonate with simple diamines, including cadaverine that was sustainably produced from lysine, under solvent-free conditions was shown to produce rigid foams. Thermogravimetric analysis carried out in tandem with infrared spectroscopy of the released gases confirmed that the foaming agent was carbon dioxide produced during the polymerisation process itself. Such a bio-based foam, being made under mild conditions from stable, benign precursors, with no toxic isocyanates, has great potential application for both thermal insulation and packaging.

Cadaverinium dichloride: A case of centro-non-centrosymmetric ambiguity

In the title salt, also known as pentane-1,5-diammonium dichloride, C 5H16N22+·2Cl-, the cation exists in an ideal fully extended conformation and lies on a mirror plane in the space group Pbam. In the crystal structure, layers of cations are hydrogen bonded with Cl- anions, which occupy the space between the layers. This kind of packing leads to a short unit-cell parameter of 4.463 (1) A. This structure is another case of centro-non-centrosymmetric ambiguity; the best results were obtained in a centrosymmetric space group, with the disordered NH3 groups accounting for the non-centrosymmetric 'component'.

Organic catalytic L - lysine chemical decarboxylation preparation 1, 5 - pentanediamine method (by machine translation)

The invention provides an organic catalytic L - lysine chemical decarboxylation preparation 1, 5 -pentanediamine, and belongs to the field 1 and 5 -pentanediamine preparation methods. The method comprises L - lysine hydrochloride as a starting raw material, adding an alkali solution, carrying out neutralization reaction at room temperature, adding a solvent or L - lysine as a starting raw material, adding a solvent, adding hydrochloric acid and stirring reaction in an aqueous phase, stirring and reacting the solvent and washing with a solvent and obtaining 1 g 5 - pentanediamine. The method has the advantages of mild reaction conditions, simple operation, cheap and easily available catalyst and solvent, recyclable reutilization, low production cost, environmental friendliness, high product yield and suitability for large-scale preparation 1 and 5 - pentanediamine products. (by machine translation)

Method for production of 1,5-pentanediamine by chemical decarboxylation of L-lysine and separation and extraction method

The invention provides a method for production of 1,5-pentanediamine by chemical decarboxylation of L-lysine and a separation and extraction method. The method of the invention comprises the followingsteps: (1) dissolving L-lysine or L-lysine hydrochloride in a citric acid-disodium hydrogen phosphate buffer solution; (2) dropwise adding an oxidizer solution into the buffer solution obtained in the Step (1), and reacting at 10-75 DEG C for 20-30 min; and (3) adding transition metal salt into a reaction solution obtained in the Step (2), and simultaneously adding a reducing agent and mixing intensely and reacting for 20-120 min so as to obtain a 1,5-pentanediamine solution. According to the invention, L-lysine or its hydrochloride is used as a raw material to undergo an oxidative decarboxylation reaction and a cyan reduction reaction to obtain 1,5-pentanediamine. The reaction has mild conditions, is easy to operate and has good repeatability. By using cation exchange resin to contact with the 1,5-pentanediamine solution, the method of the invention is low-cost and environmentally-friendly in comparison with existing 1,5-pentanediamine separation methods.

Rapid Conventional and Microwave-Assisted Decarboxylation of L-Histidine and Other Amino Acids via Organocatalysis with R-Carvone under Superheated Conditions

This article reports a new methodology taking advantage of superheated chemistry via either microwave or conventional heating for the facile decarboxylation of alpha amino acids using the recoverable organocatalyst, R-carvone. The decarboxylation of amino acids is an important synthetic route to biologically active amines, and traditional methods of amino acid decarboxylation are time consuming (taking up to several days in the case of L-histidine), are narrow in scope, and make use of toxic catalysts. Decarboxylations of amino acids including L-histidine occur in just minutes while replacing toxic catalysts with green catalyst, spearmint oil. Yields are comparable to or exceed previous methods and purification of product ammonium chloride salts is aided by an isomerization reaction of residual catalyst to phenolic carvacrol. The method has been shown to be effective for the decarboxylations of a range of natural, synthetic, and protected amino acids.

Decarboxylation of a Wide Range of Amino Acids with Electrogenerated Hypobromite

Bromide-assisted electrochemical decarboxylation efficiently produces valuable nitriles in high yields from a wide range of naturally occurring amino acids in a single step. Bromide salts are used as both redox mediators and supporting electrolytes in a simple one-compartment setup. As demonstrated for lysine, the selectivity of the decarboxylation can be tuned towards nitriles, amines or amides. An electrochemical system is developed that allows the selective decarboxylation of a wide range of amino acids. Valuable nitriles are obtained in high yields in a single step by using bromide salts as both redox mediators and supporting electrolytes. The product selectivity of lysine can be tuned towards nitriles, amines, or amides.

METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under superheated conditions in either a microwave or oil bath.

PROCESS FOR ISOLATION OF AN ORGANIC AMINE

The invention relates to a process for the isolation of an organic amine from a composition comprising the organic amine and an acid, or a salt of the organic amine and the acid, wherein the process comprises steps wherein ammonia or hydrazine is added to the composition thereby forming a multi-phase system comprising an organic amine -rich phase and an acid-rich phase, the organic amine-rich phase and the acid-rich phase obtained in step (i) are separated, and the organic amine is isolated from the organic amine -rich phase.

Tricyclic nitrogen ring compounds, their production and use

Tricyclic compound of the formula: STR1 wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.