175968-39-5

Basic information

• Product Name: 2,3-Difluoro-4-hydroxybenzoic acid
• Synonyms: 2,3-DIFLUORO-4-HYDROXYBENZOIC ACID;RARECHEM AL BO 1938;2,3-DIIFLUORO-4-HYDROXYBENZOIC ACID;4-Carboxy-2,3-difluorophenol;Benzoic acid,2,3-difluoro-4-hydroxy-
• CAS NO: 175968-39-5
• Molecular Formula: C₇H₄F₂O₃
• Molecular Weight: 174.1
• Product Categories: blocks;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorine series
• Mol File: 175968-39-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 210-211°C
• Boiling Point: 450.2°Cat760mmHg
• Flash Point: 226.1°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 0.00021mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: 2-8°C
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: 2,3-Difluoro-4-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoro-4-hydroxybenzoic acid(175968-39-5)
• EPA Substance Registry System: 2,3-Difluoro-4-hydroxybenzoic acid(175968-39-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 175968-39-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

InChI:InChI=1/C7H4F2O3/c8-5-3(7(11)12)1-2-4(10)6(5)9/h1-2,10H,(H,11,12)

Upstream product

• 144292-54-6 4-(benzyloxy)-2,3-difluorobenzoic acid 
• 144292-53-5 1-(benzyloxy)-2,3-difluorobenzene 
• 749230-30-6 (2,3-difluorophenoxy)triisopropylsilane 
• 6418-38-8 2,3-difluorophenol 
• 367-11-3 ortho-difluorobenzene 
• 1010800-88-0 2,3-difluoro-4-((triisopropylsilyl)oxy)benzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 121219-16-7 (2,3-difluorophenyl)boronic acid 

Downstream Products

• 144292-54-6 4-(benzyloxy)-2,3-difluorobenzoic acid 
• 1431531-31-5 N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2,3-difluorophenyl)-7-fluoro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide 
• 1431533-21-9 tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-2,3-difluorophenyl)-7-fluoro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)carbamate 
• 1431533-19-5 2-(4-(cyclopropylmethoxy)-2,3-difluorophenyl)-7-fluoro-1,3-benzoxazol-6-ol 
• 1431533-18-4 N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide 
• 1431533-17-3 4-(cyclopropylmethoxy)-2,3-difluorobenzoic acid 
• 1472068-00-0 2,3-difluoro-4-(hydroxymethyl)phenol 
• 1472068-03-3 4-[(2,3-difluoro-4-hydroxybenzyl)(4H-1,2,4-triazol-4-yl)amino]-benzonitrile 
• 331245-91-1 2,3-difluoro-4-(pentyloxy)benzoic acid 
• 1205681-02-2 biphenyl-2-yl-carbamic acid 1-(2-{4-[2-(2,3-difluoro-4-hydroxy-benzoylamino)-ethyl]-phenyl}-ethyl)-piperidin-4-yl ester 
• 1205552-64-2 biphenyl-2-yl-carbamic acid 1-{9-[(2,3-difluoro-4-hydroxy-benzoyl)-methyl-amino]-nonyl}-piperidin-4-yl ester 
• 1205551-93-4 Biphenyl-2-yl-carbamic acid 1-[9-(2,3-difluoro-4-hydroxy-benzoylamino)-nonyl]-piperidin-4-yl ester 
• 219685-84-4 methyl 2,3-difluoro-4-hydroxybenzoate 
• 544704-78-1 methyl 2,3-difluoro-4-methoxybenzoate 

Relevant articles and documents

V-Shaped switching and interlayer interactions in ferroelectric liquid crystals

Linear electrooptic responses in ferroelectric liquid crystals can be achieved via thresholdless switching. The molecular parameters for the design of ferroelectric liquid crystals that may yield a thresholdless response have not been delineated so far. In this article we explore some of the chemical design features that may be utilised in controlling switching processes, and we develop property-structure correlations in order to achieve materials that exhibit thresholdless behaviour. The Royal Society of Chemistry.

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives

Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substi