17597-25-0

Basic information

• Product Name: 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one
• Synonyms: 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one
• CAS NO: 17597-25-0
• Molecular Weight: 304.43
• Mol File: 17597-25-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one(17597-25-0)
• EPA Substance Registry System: 17β-hydroxy-4α,5-epoxy-5α-androstan-3-one(17597-25-0)

Safety Data

• Hazardous Substances Data: 17597-25-0(Hazardous Substances Data)

Upstream product

• 1221910-14-0 17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 1045-69-8 testosterone acetate 
• 58-22-0 testosterone 

Downstream Products

• 4075-14-3 2alpha-Hydroxytestosterone 
• 2141-17-5 4-hydroxytestosterone 
• 2141-17-5 4-Hydroxy-testosteron 

Relevant articles and documents

Lithium naphthalenide induced reductive cleavage of α,β-epoxy ketones: An efficient procedure for the preparation of β-hydroxy ketones

Lithium naphthalenide presents itself as a mild and efficient reagent for the cleavage of α,β-epoxy ketones to give the corresponding β-hydroxy ketones in good yields.

Unambiguous assignment of 13C NMR signals in epimeric 4,5-epoxy-3-oxo-steroids assisted by X-ray diffraction and Gauge Invariant Atomic Orbitals calculation of absolute isotropic shieldings

Complete assignments of the 13C signals of diastereomeric 4,5-epoxy-3-oxo steroids based on a combination of 1D and 2D NMR techniques are described The assignments were corroborated or corrected by calculation of the absolute isotropic 13C NMR shieldings using the Gauge Invariant Atomic Orbitals (GIAO) method at B3LYP/6-31+G(d,p) level. ARKAT-USA, Inc.

Highly efficient alkene epoxidation and aziridination catalyzed by iron(II) salt + 4,4′,4″-trichloro-2,2′:6′,2″-terpyridine/ 4,4″-dichloro-4′-O-PEG-OCH3-2,2′:6′,2″- terpyridine

(Chemical Equation Presented) "Iron(II) salt + 4,4′,4″- trichloro-2,2′:6′,2″-terpyridine" is an effective catalyst for epoxidation and aziridination of alkenes and intramolecular amidation of sulfamate esters. The epoxidation of allylic-substituted cycloalkenes achieved excellent diastereoselectivities up to 90%. ESI-MS results supported the formation of iron-oxo and -imido intermediates. Derivitization of Cl3terpy to O-PEG-OCH3-Cl2terpy renders the terpyridine unit to be recyclable, and the "iron(II) salt + 4,4″-dichloro-4′-O-PEG-OCH3-2,2′:6′,2″- terpyridine" protocol can be reused without a significant loss of catalytic activity in the alkene epoxidation.