175978-40-2Relevant academic research and scientific papers
Toward the solid-phase synthesis of heparan sulfate oligosaccharides: Evaluation of iduronic acid and idose building blocks
Guedes, Nerea,Czechura, Pawel,Echeverria, Begona,Ruiz, Ada,Michelena, Olatz,Martin-Lomas, Manuel,Reichardt, Niels-Christian
, p. 6911 - 6934 (2013/08/23)
Glycan arrays have been established as the premier technical platform for assessing the specificity of carbohydrate binding proteins, an important step in functional glycomics research. Access to large libraries of well-characterized oligosaccharides rema
L-Iduronic acid derivatives as glycosyl donors
Tabeur, Christine,Machetto, Francoise,Mallet, Jean-Maurice,Duchaussoy, Philippe,Petitou, Maurice,Sinay, Pierre
, p. 253 - 276 (2007/10/03)
O-[Methyl (2-O-acetyl-3-O-benzyl-4-O-levulinyl-α, and β-L-idopyranosid)uronate]trichloroacetimidate and the corresponding n-pentenyl glycosides are efficient L-iduronic acid glycosyl donors. Both have been used for the high-yielding synthesis of basic disaccharide blocks which are useful for the subsequent synthesis of complex oligosaccharides related to heparin/heparan sulfate, and dermatan sulfate. In contrast, the corresponding thioethyl glycosides, thiophenyl glycosides, and fluoride, did not yield the expected disaccharides.
