17598-96-8

Usage

Uses

Used in Pharmaceutical Industry:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diol is used as a solubility enhancer for improving the water solubility of poorly soluble drugs, facilitating their absorption and bioavailability.
Used in Drug Delivery Systems:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diol is used as a component in the design of drug delivery systems, such as nanoparticles, liposomes, and hydrogels, to improve the stability, targeting, and controlled release of therapeutic agents.
Used in Cosmetics Industry:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diol is used as a humectant to help retain moisture in the skin, providing hydration and improving the skin's appearance.
Used in Biomedical Research:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diol is used as a versatile building block for the synthesis of biocompatible polymers and macromolecules, which can be utilized in tissue engineering, diagnostics, and therapeutic applications.

InChI:InChI=1/C26H54O14/c27-1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-23-39-25-26-40-24-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-28/h27-28H,1-26H2

Upstream product

• 4792-15-8 Pentaethylene glycol 
• 41024-91-3 penta(ethylene glycol) bis(p-toluenesulfonate) 
• 111-77-3 2-(2-methoxyethoxy)ethyl alcohol 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-60-7 Tetraethylene glycol 
• 128660-97-9 2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethan-1-ol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 80322-82-3 triethyleneglycol dimesylate 
• 57671-28-0 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 361543-06-8 C₄₀H₆₆O₁₄ 

Downstream Products

• 361543-12-6 PEODA₁₃ 
• 141320-76-5 tridecaethylene glycol 5-<(2',6'-di-tert-butyl-4-methyl)phenoxy>pentanoate 
• 141320-77-6 tridecaethylene glycol 5-<(3',5'-di-tert-butyl)phenoxy>pentanoate 
• 141320-80-1 tridecaethylene glycol monotrityl ether 

Relevant academic research and scientific papers

Supramolecular surfactants: Polymerized bolaphiles exhibiting extraordinarily high membrane-disrupting activity

Polymerized forms of saturated, olefinic, and acetylenic bolaphiles (double-headed surfactants) have been prepared by condensation of a series of α,ω-dicarboxylic acids with tridecaethylene glycol, and evaluated for their ability to induce the release of 5(6)-carboxyfluorescein (CF) entrapped within large unilamellar vesicles derived from 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). Each amphiphilic polymer was found to have substantially greater membrane-disrupting activity than that found for Triton X-100; operationally, one was more than 300 times greater in activity. Comparison of each supramolecular surfactant with its corresponding bolaphile demonstrates, in nearly all cases, that a significant enhancement in membrane-disrupting activity is provided through polymerization, and that the magnitude of this amplification decreases, exponentially, as the length of the hydrophobic segment increases. In the most striking case, the disruptive power of the supramolecular surfactant was at least 3 orders of magnitude greater than its monomeric counterpart. As one goes from saturated to olefinic to acetylenic polyesters, longer hydrophobic segments are required in order to reach a maximum in activity. From a practical standpoint, supramolecular surfactants extend nonionic detergents into a new and uncharted domain in membrane-disrupting activity.

Synthesis of poly(ethylene oxide) approaching monodispersity

Polydispersity in polymers hinders fundamental understanding of their structure-property relationships and prevents them from being used in fields like medicine, where polydispersity affects biological activity. The polydispersity of relatively short-chain poly(ethylene oxide) [(CH 2CH2O2)n; PEO] affects its biological activity, for example, the toxicity and efficacy of PEOylated drugs. As a result, there have been intensive efforts to reduce the dispersity as much as possible (truly monodispersed materials are not possible). Here we report a synthetic procedure that leads to an unprecedented low level of dispersity. We also show for the first time that it is possible to discriminate between PEOs differing in only 1 ethylene oxide (EO) unit, essential in order to verify the exceptionally low levels of dispersity achieved here. It is anticipated that the synthesis of poly(ethylene oxide) approaching monodispersity will be of value in many fields where the applications are sensitive to the distribution of molar mass.

Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide

A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (-)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displacement assays. Key reactions include a new alkoxide-mesylate displacement for the assembly of the PEG linkers and a double Sonogashira coupling reaction.