1760-71-0

Usage

Uses

Used in Personal Care and Cosmetic Products:
4-Chloro-6-nitro-o-cresol is used as a preservative in personal care and cosmetic products to prevent microbial growth and extend the shelf life of these products.
Used in Pharmaceuticals:
In the pharmaceutical industry, 4-chloro-6-nitro-o-cresol is used as a preservative in various formulations to ensure the stability and safety of the products.
Used in Industrial Applications:
4-Chloro-6-nitro-o-cresol is also used in industrial applications as a preservative to protect materials from microbial contamination.
However, there are concerns regarding the potential toxicity and environmental impact of 4-chloro-6-nitro-o-cresol, leading to restrictions on its use in certain countries. 4-chloro-6-nitro-o-cresol is also known for its skin sensitizing properties and can cause allergic reactions in some individuals. Due to these factors, efforts are being made to find alternative preservatives that are less harmful to human health and the environment.

InChI:InChI=1/C7H6ClNO3/c1-4-2-5(8)3-6(7(4)10)9(11)12/h2-3,10H,1H3

Upstream product

• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 635-93-8 5-chlorosalicyclaldehyde 
• 1570-64-5 2-methyl-4-chlorophenol 
• 1570-65-6 4,6-dichloro-2-methylphenol 

Downstream Products

• 93794-45-7 5-chloro-2-mercapto-7-methylbenzoxazole 
• 1760-73-2 4-Chlor-6-amino-2-methyl-anisol 
• 1760-72-1 4-Chlor-6-nitro-2-methyl-anisol 
• 2300-68-7 <4-Chlor-2-methyl-6-nitro-phenoxy>-essigsaeure-ethylester 
• 80526-44-9 2-amino-4-chloro-6-methylphenol 

Relevant academic research and scientific papers

Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT3 receptor

5-HT3 receptor is an attractive target for the development of therapeutic agents for use in brain, heart and cancer diseases, and imaging agents for use in biomedical imaging technique PET. Benzoxazole derivatives are a novel class of 5-HT3 receptor partial agonists with high binding affinity. Carbon-11 labeled benzoxazole derivatives have been synthesized as new potential PET radioligands for imaging 5-HT3 receptor. The target tracers were prepared by N-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by HPLC purification procedure in 40-50% radiochemical yields, which were decay corrected to the end of bombardment (EOB), based on [11C]CO2. The overall synthesis time was 20-25 min from EOB. The radiochemical purity was >99%, and specific activity was in a range of 74-111 GBq/μmol at the end of synthesis (EOS).

Carboxylic Acid Compounds and Use Thereof

Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: [image] wherein each symbol is as defined in the specification.

Formation of 4-Halo-4-nitrocyclohexa-2,5-dienones on Nitration of p-Halophenols and p-Halophenyl Acetates.

Nitration of p-chloro-, p-fluoro-, and p-bromo-phenol or the corresponding p-halophenyl acetates at -40 deg C and below gives the 4-halo-4-nitrocyclohexa-2,5-dienones in addition to the 4-halo-2-nitrophenols.The dienones isomerize to the nitrophenols at temperatures between -40 deg C and 0 deg C.Nitration of 4-chloro-2-methylphenol or its acetate gives both 4-chloro-2-methyl-4-nitrocyclohexa-2,5-dienone and 4-chloro-6-methyl-6-nitrocyclohexa-2,4-dienone. 4-Chloro-3-methylphenol and its acetate give 4-chloro-3-methyl-4-nitrocyclohexa-2,5-dienone.