1760-71-0

Basic information

• Product Name: 4-chloro-6-nitro-o-cresol
• Synonyms: 4-chloro-6-nitro-o-cresol
• CAS NO: 1760-71-0
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58044
• EINECS: 217-165-1
• Mol File: 1760-71-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 264.8°Cat760mmHg
• Flash Point: 113.9°C
• Appearance: /
• Density: 1.466g/cm³
• Vapor Pressure: 0.00582mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 4-chloro-6-nitro-o-cresol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-nitro-o-cresol(1760-71-0)
• EPA Substance Registry System: 4-chloro-6-nitro-o-cresol(1760-71-0)

Safety Data

• Hazardous Substances Data: 1760-71-0(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-nitro-o-cresol, also known as PCMC, is a chemical compound used primarily as a preservative in various products such as personal care and cosmetic products, pharmaceuticals, and industrial applications. It is a colorless to pale yellow crystalline powder with a faint phenolic odor. PCMC is effective against a wide range of microorganisms, including bacteria and fungi. However, there are concerns regarding its potential toxicity and environmental impact, leading to restrictions on its use in certain countries. The compound is also known for its skin sensitizing properties and can cause allergic reactions in some individuals. Due to these factors, efforts are being made to find alternative preservatives that are less harmful to human health and the environment.

InChI:InChI=1/C7H6ClNO3/c1-4-2-5(8)3-6(7(4)10)9(11)12/h2-3,10H,1H3

Upstream product

• 1570-65-6 4,6-dichloro-2-methylphenol 
• 635-93-8 5-chlorosalicyclaldehyde 
• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 1570-64-5 2-methyl-4-chlorophenol 

Downstream Products

• 1760-72-1 4-Chlor-6-nitro-2-methyl-anisol 
• 1760-73-2 4-Chlor-6-amino-2-methyl-anisol 
• 93794-45-7 5-chloro-2-mercapto-7-methylbenzoxazole 
• 2300-68-7 <4-Chlor-2-methyl-6-nitro-phenoxy>-essigsaeure-ethylester 
• 80526-44-9 2-amino-4-chloro-6-methylphenol 

Relevant articles and documents

Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT3 receptor

5-HT3 receptor is an attractive target for the development of therapeutic agents for use in brain, heart and cancer diseases, and imaging agents for use in biomedical imaging technique PET. Benzoxazole derivatives are a novel class of 5-HT3 receptor partial agonists with high binding affinity. Carbon-11 labeled benzoxazole derivatives have been synthesized as new potential PET radioligands for imaging 5-HT3 receptor. The target tracers were prepared by N-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by HPLC purification procedure in 40-50% radiochemical yields, which were decay corrected to the end of bombardment (EOB), based on [11C]CO2. The overall synthesis time was 20-25 min from EOB. The radiochemical purity was >99%, and specific activity was in a range of 74-111 GBq/μmol at the end of synthesis (EOS).

Formation of 4-Halo-4-nitrocyclohexa-2,5-dienones on Nitration of p-Halophenols and p-Halophenyl Acetates.

Nitration of p-chloro-, p-fluoro-, and p-bromo-phenol or the corresponding p-halophenyl acetates at -40 deg C and below gives the 4-halo-4-nitrocyclohexa-2,5-dienones in addition to the 4-halo-2-nitrophenols.The dienones isomerize to the nitrophenols at temperatures between -40 deg C and 0 deg C.Nitration of 4-chloro-2-methylphenol or its acetate gives both 4-chloro-2-methyl-4-nitrocyclohexa-2,5-dienone and 4-chloro-6-methyl-6-nitrocyclohexa-2,4-dienone. 4-Chloro-3-methylphenol and its acetate give 4-chloro-3-methyl-4-nitrocyclohexa-2,5-dienone.