176018-91-0

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 184784-56-3 N-(4'-methyl-2'-pentenoyl)-4S-phenyl-1,3-oxazolidin-2-one 
• 611-70-1 phenyl isopropyl ketone 
• 77921-03-0 (E)-4-methyl-3-phenyl-2-pentenoic acid 
• 1775-44-6 (2E)-4-methylpent-2-enoic acid 

Downstream Products

• 199468-78-5 (S)-3-((2S,3S)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 199468-80-9 (S)-3-((2R,3S)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 199468-83-2 (2R,3S)-2-azido-3-phenylisohexanoic acid 
• 199468-81-0 (2S,3S)-2-azido-3-phenylisohexanoic acid 
• 199468-77-4 (S)-3-((2S,3S)-2-Bromo-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis and conformational features of topographically constrained designer chimeric amino adds: The β-isopropyl phenylalanines

All four optically pure isomers of the highly conformationally constrained novel chimeric amino acid, β-isopropylphenylalanine or β- phenylleucine, were asymmetrically synthesized in five to six steps in 20 - 25% overall yield. Computer-assisted molecular modeling revealed that the β- isopropyl group in these chimeric amino acids plays the dominant role in determining the most favorable side chain conformations.

Asymmetric synthesis of optically pure β-isopropylphenylalanine: A new β-branched unusual amino acid

All four optically pure isomers of a highly conformationally constrained unusual amino acid, β-isopropylphenylalanine, have been asymmetrically synthesized.

Syntheses of highly constrained β-aryl isohexanoic acid derivatives via asymmetric Michael addition

A series of enantiomerically pure highly sterically hindered β-branched isohexanoic acid derivatives have been synthesized with high diastereoselectivity via asymmetric Michael addition. The X-ray crystal structure of (4S,3'S)-3-[3'-(2,6-dimethylphenyl)is