176094-83-0Relevant academic research and scientific papers
Pd-Catalyzed C-S Activation/Isocyanide Insertion/Hydrogenation Enables a Selective Aerobic Oxidation/Cyclization
Chang, Jian,Liu, Bangyu,Yang, Yang,Wang, Mang
supporting information, p. 3984 - 3987 (2016/09/09)
Unique imidoylation of thioorganics with isocyanides endows an unprecedented aerobic oxidation process. Catalyzed by Pd(Ph3P)2Cl2 in the presence of Ph3SiH under N2 then upon exposure to air, a wide range of α-acyl ketene dithioacetals react with isocyanides to afford 5-hydroxy-α,β-unsaturated γ-lactams via a C-S bond activation, isocyanide migratory insertion, hydrogenation, selective aerobic oxidation, and intramolecular nucleophilic addition sequence.
Regio- and stereoselective synthesis of 2-cyclopentenones via a hydrogenolysis-terminated Heck cyclization of β-alkylthio dienones
Liu, Bangyu,Zheng, Gang,Liu, Xiaocui,Xu, Cong,Liu, Jingxin,Wang, Mang
supporting information, p. 2201 - 2203 (2013/04/10)
Palladium-catalyzed cyclization of β-alkylthio dienone derivatives affords 2-cyclopentenones in a regio- and stereoselective manner in the presence of silane. C-S activation, intramolecular carbopalladation and hydrogenolysis construct the cascade process
Unexpected hydrobromic acid-catalyzed C-C bond-forming reactions and facile synthesis of coumarins and benzofurans based on ketene dithioacetals
Yuan, Hongjuan,Wang, Mang,Liu, Yingjie,Wang, Lili,Liu, Jun,Liu, Qun
experimental part, p. 13450 - 13457 (2011/02/27)
Hydrobromic acid was found to be a unique catalyst in C-C bond-forming reactions with ketene dithioacetals. Distinctly different from other acids (including Lewis and Bronsted acids), the remarkable catalytic performance of hydrobromic acid in catalytic a
Synthesis of functionalized allylic sulfoxides and their use in the construction of 2,3,4-trisubstituted furans via a [3 + 2] annulation
Fu, Zhenqian,Wang, Mang,Ma, Yuhui,Liu, Qun,Liu, Jun
, p. 7625 - 7630 (2008/12/22)
(Chemical Equation Presented) A route to 2,3,4-trisubstituted furan derivatives based on a [3 + 2] annulation of functionalized allylic sulfoxides and aldehydes is described. In this strategy, the precursors of allylic sulfoxides 4, allylic sulfides 3, were synthesized via a thiomethylation reaction of an α-EWG ketene-S,S-acetal 1 (EWG: electron-withdrawing group), formaldehyde, and a thiol 2 in high to excellent yields. Allylic sulfoxides 4 were prepared by a highly regioselective oxidation of 3, using m-chloroperoxybenzoic acid as oxidant. Thus, starting from these readily available sulfoxides 4, 2-alkylthio-3,4-disubstituted furans 6 were efficiently constructed via the [3 + 2] annulation reaction of 4 with aldehydes 5 under mild conditions. Further replacement of the 2-alkylthio group of 6 with amines led to the formation of 2-amino-3,4-disubstituted furan derivatives 7.
[5 + 1] Annulation: A synthetic strategy for highly substituted phenols and cyclohexenones
Bi, Xihe,Dong, Dewen,Liu, Qun,Pan, Wei,Zhao, Lei,Li, Bing
, p. 4578 - 4579 (2007/10/03)
A novel [5 + 1] annulation strategy is developed for the synthesis of highly substituted phenols and cyclohexenones from α-alkenoyl ketenedithioacetals and nitroalkanes. Copyright
