54848-86-1

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 180071-77-6 (E)-ethyl-3-<((2-methylphenyl)dimethylsilyl)methoxy>-propenoate 
• 180071-78-7 Methanesulfonic acid (E)-2-{3-[(dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynyl ester 
• 1027646-67-8 (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester 
• 180071-76-5 2-<3-<((2-methylphenyl)dimethylsilyl)methoxy>benzyl>-8,8-dimethyl-non-4-ene-6-ynol 
• 180071-79-8 ethyl-3-<((2-methylphenyl)dimethylsilyl)methoxy>propinoate 
• 176100-05-3 [(Dimethyl-o-tolyl-silanyl)-methyl]-(3-ethylaminomethyl-phenyl)-amine 
• 176100-04-2 3-{[(Dimethyl-o-tolyl-silanyl)-methyl]-amino}-benzaldehyde 
• 54848-87-2 (o-bromomethylphenyl)dimethylchloromethylsilane 
• 176100-03-1 N-(3-Cyano-phenyl)-N-[(dimethyl-o-tolyl-silanyl)-methyl]-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

A convergent and straightforward synthetic method to prepare deaza-analogs of squalene epoxidase inhibitors

A general route to deaza-analogs of squalene epoxidase inhibitors of general formula A is described using a very convergent synthetic scheme illustrated by the preparation of compound 2b. A Heck reaction, and an enolate condensation with an appropriate electrophile are the key steps of the expedient elaboration of 2b or analogs.

Silyl modification of biologically active compounds. 3. Organosilicon derivatives of aminoalcohols in the series of tetrahydroquinoline, tetrahydroisoquinoline, and tetrahydrosilaisoquinoline

The N-(2′-hydroxyethyl)-1,2,3,4-tetrahydroquinoline, -isoquinoline, and -silaisoquinoline, and their trimethyl-and triethylsilyl derivatives and the corresponding methiodides were synthesized. The acute toxicity and psychotropic activity of the compounds synthesized were studied. 1997 Plenum Publishing Corporation.