176175-97-6

Basic information

• Product Name: 1-(benzyloxy)-3,5-difluorobenzene
• Synonyms: 1-(benzyloxy)-3,5-difluorobenzene;1,3-difluoro-5-(phenylmethoxy)benzene
• CAS NO: 176175-97-6
• Molecular Formula: C₁₃H₁₀F₂O
• Molecular Weight: 220.2147064
• Mol File: 176175-97-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 266.001 °C at 760 mmHg
• Flash Point: 121.942 °C
• Appearance: /
• Density: 1.206 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(benzyloxy)-3,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-3,5-difluorobenzene(176175-97-6)
• EPA Substance Registry System: 1-(benzyloxy)-3,5-difluorobenzene(176175-97-6)

Safety Data

• Hazardous Substances Data: 176175-97-6(Hazardous Substances Data)

Usage

General Description

1-(Benzyloxy)-3,5-difluorobenzene is a chemical compound with the molecular formula C13H11F2O. It is a derivative of benzene, with two fluorine atoms attached to the 3 and 5 positions, and a benzyloxy group attached to the 1 position. 1-(Benzyloxy)-3,5-difluorobenzene is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. It is also used as a starting material in the production of agrochemicals and fine chemicals. The presence of the fluorine atoms in the compound’s structure can impart unique properties that make it useful in a wide range of applications.

Upstream product

• 2713-34-0 3,5-difluorophenol 
• 100-39-0 benzyl bromide 
• 372-38-3 1,3,5-trifluorobenzene 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Regioselective approach to multisubstituted benzenes

Various multisubstituted benzenes were synthesized in highly chemo- and regioselective manners via nucleophilic aromatic substitution and ortho-metalation from 1,3,5-trifluorobenzene.

Total Syntheses of Perenniporides

The total syntheses of perenniporide A (1) and related compounds have been achieved. Starting from 1,3,5-trifluorobenzene (9), difluorodienone 6 was obtained by oxidative dearomatization, which served as a platform for the high-pressure cycloaddition and for the introduction of the C3-methoxy group. The synthesis allowed access to the natural congeners 2 and 3, enabling assignment of the absolute structures of these natural products.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.