1762-45-4Relevant articles and documents
Spin Crossover Behavior in a Homologous Series of Iron(II) Complexes Based on Functionalized Bipyridyl Ligands
Xue, Shufang,Guo, Yunnan,Rotaru, Aurelian,Müller-Bunz, Helge,Morgan, Grace G.,Trzop, Elzbieta,Collet, Eric,Oláh, Julianna,Garcia, Yann
, p. 9880 - 9891 (2018)
A series of bulky substituted bipyridine-related iron(II) complexes [Fe(H2Bpz2)2(L)] (pz = pyrazolyl) were prepared, where L = 5,5′-dimethyl-2,2′-bipyridine (bipy-CH3, 1), L = dimethyl-2,2′-bipyridyl-5,5′-dicarboxylate (MeObpydc, 2), L = diethyl-2,2′-bipyridyl-5,5′-dicarboxylate (EtObpydc, 3), or L = diisopropyl-2,2′-bipyridine-5,5′-dicarboxylate (i-PrObpydc, 4). The crystal structures of five new iron(II) complexes were determined by X-ray diffraction: those of 1, 3, and 4 and two modifications of 3 (3B) and 4 (4B). Complexes 1 and 3B display incomplete spin crossover (SCO) behavior because of a freezing-in effect, whereas 3 and 4B undergo gradual and incomplete SCO behaviors. Complexes 2 and 4 show a completely gradual and steep SCO, respectively. Such different SCO behaviors can be attributed to an electronic substituent effect in the bipyridyl ligand conformation and a crystal packing effect. Importantly, the electronic substituent effect of the isopropyl acetate group and C-H···O supramolecular interactions in 4 contribute to a highly cooperative behavior, which leads to an abrupt thermally induced spin transition.
INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE
-
Paragraph 0297; 0298; 0299, (2016/10/17)
Biheteroaryl dicarboxylates and esters, and salts thereof which are useful as modulators of CP4H activity and more particularly as inhibitors of CP4H. Compounds of formula: and salts thereof where: X is S, O, NH, or NR, where R is an alkyl group having 1-3 carbon atoms; R1 and R2 independently are —OR7, or —NHSO2R8, where R7 is selected from: hydrogen, alkyl, alkenyl, alkoxyalkyl, —R′—CO—R″, —R′—CO—O—R″, —CO—R″, —R′—O—CO—R″, —R′—CO—NR″, —CO—NR″, or —R′—O—CO—NR″, and R8 is selected from hydrogen, alkyl, aryl, arylalkyl; R3, R4 and R6 independently are hydrogen, alkyl, alkoxy, alkenyl, alkenoxy, halo alkyl, haloalkenyl, halogen, hydroxyl, hydroxyalkyl, hydroxyalkenyl, aryl, aryloxy, arylalkyl or arylalkyloxy; R5 is hydrogen, halogen, alkyl having 1-3 carbon atoms, or alkoxy having 1-3 carbon atoms; —R′— is a divalent straight chain or branched alkylene, and —R″ is an alkyl, alkenyl, arylalkyl, or aryl group. Methods for inhibition of CP4H in vivo and in vitro.
A molecular Pd(ii) complex incorporated into a MOF as a highly active single-site heterogeneous catalyst for C-Cl bond activation
Chen, Liyu,Rangan, Sylvie,Li, Jing,Jiang, Huanfeng,Li, Yingwei
, p. 3978 - 3985 (2014/08/05)
The organic palladium complex Pd(H2bpydc)Cl2 (H 2bpydc = 2,2′-bipyridine-5,5′-dicarboxylic acid) was immobilized on a porous metal-organic framework UiO-67 (Zr6O 4(OH)4(bpdc)6, bpdc = para- biphenyldicarboxylate) using a direct incorporation strategy. The use of a large amount of the H2bpdc ligand (90 mol% of the mixed ligands) that can't chelate the Pd complex allowed the formation of isolated Pd single active sites uniformly distributed in the MOF network. Pd(ii) doped UiO-67 is isostructural to the parent UiO-67 framework, with a high surface area and pore volume of ca. 2000 m2 g-1 and 0.79 cm3 g -1, respectively. The material was highly efficient in the catalytic conversion of aryl chlorides, showing remarkably higher activity than the homogeneous Pd counterparts. High yields were achieved in Heck and Suzuki-Miyaura coupling reactions of chloroarenes bearing a wide range of substituents. Moreover, the catalyst was recoverable and reusable, giving essentially identical activity after at least 5 cycles. The combination of the advantages of both homogeneous molecular Pd catalysts and solid MOF structures in this system may bring new opportunity in the development of highly active heterogeneous palladium catalysts for a variety of Pd-catalyzed transformations. This journal is the Partner Organisations 2014.
