176257-50-4Relevant articles and documents
Glycosamino acids: New building blocks for combinatorial synthesis
McDevitt, Jason P.,Lansbury Jr., Peter T.
, p. 3818 - 3828 (2007/10/03)
In order to produce inexpensive, chemically diverse carbohydrate building blocks more amenable for use in combinatorial organic synthesis, amine and carboxylic acid functional groups were incorporated into several monosaccharides. A series of 12 new glycosamino acids was prepared from commercially available starting materials. Conventional peptide synthesis solution coupling techniques were used to ligate glycosamino acids, producing oligomeric 'glycotides'. Finally, a library of glycotides was produced by coupling of a glycosamino acid mixture to a rigid template.