1763-02-6

Usage

InChI:InChI=1/C9H12IN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7?/m0/s1

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 
• 1313031-57-0 5-iodo-5'-O-[cyclo-3,5-di(tert-butyl)-6-fluorosaligenyl]-2'-deoxyuridine monophosphate 
• 1313031-73-0 5-iodo-5'-O-[cyclo-3,5-di(tert-butyl)-6-fluorosaligenyl]-2'-deoxyuridine monophosphate 
• 1150314-85-4 5-[⁽¹²⁵⁾I]iodo-5'-O-cyclosaligenyl-2'-deoxyuridine monophosphate 
• 1150314-84-3 5-[⁽¹²⁵⁾I]iodo-5'-O-cyclosaligenyl-2'-deoxyuridine monophosphate 
• 1146167-61-4 5-iodo-3'-O-levulinyl-2'-deoxyuridine 
• 1209526-88-4 5-iodo-5'-O-trityl-3'-O-levulinyl-2'-deoxyuridine 

Downstream Products

• 76756-33-7 5-(2,5-dimethoxyphenyl)-2'-deoxyuridine 5'-phosphate 

Relevant academic research and scientific papers

Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2′-deoxyuridine, 5-iodo-3′-fluoro-2′,3′-dideoxyuridine, and 3′-fluorothymidine for molecular radiotherapy of cancer: Synthesis and biological evaluation

Targeted molecular radiotherapy opens unprecedented opportunities to eradicate cancer cells with minimal irradiation of normal tissues. Described in this study are radioactive cyclosaligenyl monophosphates designed to deliver lethal doses of radiation to cancer cells. These compounds can be radiolabeled with SPECT- and PET-compatible radionuclides as well as radionuclides suitable for Auger electron therapies. This characteristic provides an avenue for the personalized and comprehensive treatment strategy that comprises diagnostic imaging to identify sites of disease, followed by the targeted molecular radiotherapy based on the imaging results. The developed radiosynthetic methods produce no-carrier-added products with high radiochemical yield and purity. The interaction of these compounds with their target, butyrylcholinesterase, depends on the stereochemistry around the P atom. IC50 values are in the nanomolar range. In vitro studies indicate that radiation doses delivered to the cell nucleus are sufficient to kill cells of several difficult to treat malignancies including glioblastoma and ovarian and colorectal cancers.