176317-02-5

Basic information

• Product Name: 2,3,4-Trifluorobromobenzene
• Synonyms: 1-BROMO-2,3,4-TRIFLUOROBENZENE;2,3,4-TRIFLUOROBROMOBENZENE;2,3,4-Trifluoro-1-bromobenzene;1-Bromo-2,3,4-trifluorobenzene, 97% 2,3,4-Trifluorobromobenzene];1-Bromo-2,3,4-trifluorobenzene 99%;1-Bromo-2,3,4-trifluorobenzene99%;2,3,4-Trifluorobromo;4-TrifluorobroMobenzene
• CAS NO: 176317-02-5
• Molecular Formula: C₆H₂BrF₃
• Molecular Weight: 210.98
• EINECS: -0
• Product Categories: Other fluorin-contained compounds;Fluorobenzene Series;Aromatic Halides (substituted);API intermediates;Miscellaneous;Benzenes;Fluorine series
• Mol File: 176317-02-5.mol

Chemical Properties

• Boiling Point: 47-47 °C (60 mmHg)
• Flash Point: 144 °F
• Appearance: Clear pale yellow liquid
• Density: 1.777 g/mL at 25 °C(lit.)
• Vapor Pressure: 4.43mmHg at 25°C
• Refractive Index: n20/D 1.487(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• BRN: 7805451
• CAS DataBase Reference: 2,3,4-Trifluorobromobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-Trifluorobromobenzene(176317-02-5)
• EPA Substance Registry System: 2,3,4-Trifluorobromobenzene(176317-02-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39-36
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 176317-02-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4-Trifluorobromobenzene is used as a synthetic intermediate for the production of 5-nitro-6-methylquinoline carboxylic acid, which is an important compound in the pharmaceutical industry. The application reason is that this compound serves as a key building block in the synthesis of various drug molecules, particularly those with potential therapeutic applications.
Used in Chemical Synthesis:
2,3,4-Trifluorobromobenzene is used as a versatile reagent in chemical synthesis for the preparation of a wide range of organic compounds. The application reason is its unique combination of fluorine and bromine atoms, which allows for various synthetic transformations and functional group manipulations, leading to the formation of diverse molecular structures with potential applications in various industries.

InChI:InChI=1/C6H2BrF3/c7-3-1-2-4(8)6(10)5(3)9/h1-2H

Upstream product

• 3862-73-5 2,3,4-trifluoroaniline 
• 1489-53-8 1,2,3-trifluorobenzene 

Downstream Products

• 193533-92-5 4-methyl-1,2,3-trifluorobenzene 
• 220987-81-5 1-bromo-4,5,6-trifluoro-2-[(4-methoxyphenyl)aminosulfonyl]benzene 
• 220987-80-4 1-Bromo-2,3,4-trifluoro-5-[(4-methoxyphenyl)aminosulfonyl]benzene 
• 459424-72-7 1-iodo-2,3,4-trifluorobenzene 
• 530145-56-3 (5-bromo-2,3,4-trifluorophenyl)triethylsilane 
• 212631-85-1 3-bromo-4,5,6-trifluorobenzoic acid 
• 530145-57-4 1-bromo-2,3,4-trifluoro-5-iodobenzene 
• 65829-28-9 2,3,4-Trifluor-5-methylbenzoesaeure 
• 193533-94-7 1-(2,3,4-Trifluoro-5-methyl-phenyl)-ethanone 
• 194782-89-3 2,3,4-Trifluoro-5-methyl-6-nitro-benzoic acid 
• 194782-90-6 3-Oxo-3-(2,3,4-trifluoro-5-methyl-6-nitro-phenyl)-propionic acid ethyl ester 
• 194782-91-7 (Z)-3-Cyclopropylamino-2-(2,3,4-trifluoro-5-methyl-6-nitro-benzoyl)-acrylic acid ethyl ester 
• 103557-21-7 1,1-bis(4-trifluoromethoxyphenyl)-2-(1,2,3,4-2H-tetrazol-2-yl)propan-1-ol 
• 819861-95-5 1-(3-methyl-3-hydroxy-1-butynyl)-2,3,4-trifluorobenzene 

Relevant articles and documents

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Organometallic control over the regiospecificity of functionalization reactions: 1,2,3-Trifluorobenzene and bromo derivatives thereof as substrates

In a case study, 1,2,3-trifluorobenzene was functionalized at each of the two vacant positions (producing the benzoic acids 1 and 2) and, in addition, bromine was introduced into all available positions (producing the benzoic acids 3-5). The required regioflexibility was achieved by applying novel organometallic recipes such as deprotonation-triggered halogen migrations and site-discriminating competitive halogen-metal permutations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Novel 5-amino-6-methylquinolone antibacterials: A new class of non-6-fluoroquinolones

A novel 5-amino-6-methylquinoline carboxylic acid was synthesized from 2,3,4-trifluoro aniline in 12 steps and coupled with various types of amines to furnish new quinolone antibacterial agents. Depending on the structure of amine, some of quinolones showed comparable activity to ciprofloxacin or better Gram positive activity than ciprofloxacin, demonstrating that the C6 fluorine atom is not a necessary requirement for good antibacterial potency.