176379-63-8

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-(dimethylamino)-1-(4-fluorophenyl)-3-methyl-
• CAS NO: 176379-63-8
• Molecular Formula: C13H14FN3O2
• Molecular Weight: 263.271
• Mol File: 176379-63-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-(dimethylamino)-1-(4-fluorophenyl)-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-(dimethylamino)-1-(4-fluorophenyl)-3-methyl-(176379-63-8)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-(dimethylamino)-1-(4-fluorophenyl)-3-methyl-(176379-63-8)

Safety Data

• Hazardous Substances Data: 176379-63-8(Hazardous Substances Data)

Upstream product

• 124-40-3 dimethyl amine 
• 301206-17-7 6-chloro-1-(4-fluorophenyl)-3-methyluracil 
• 19677-81-7 1-(4-fluoro-phenyl)-3-methyl-pyrimidine-2,4,6-trione 
• 301206-16-6 1-(2-Cyano-acetyl)-3-(4-fluoro-phenyl)-1-methyl-urea 
• 19369-30-3 6-amino-1-(4-fluoro-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 772-55-4 N-(4-fluorophenyl)-N'-methyl-urea 

Downstream Products

• 176378-95-3 acetic acid 3-acetoxy-5-[6-dimethylamino-1-(4-fluoro-phenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-phenyl ester 
• 595558-89-7 5-(3,5-di-tert-butyl-4-hydroxyphenylcarboxamido)-6-dimethylamino-1-(4-fluorophenyl)-3-methyl-2,4-(1H,3H)-pyrimidinedione 
• 176379-64-9 5-amino-6-dimethylamino-1-(4-fluorophenyl)-3-methyluracil 
• 301206-18-8 6-dimethylamino-1-(4-fluoro-phenyl)-3-methyl-5-nitro-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.