772-55-4

Basic information

• Product Name: 1-Methyl-3-(4-fluorophenyl)urea
• Synonyms: 1-(p-Fluorophenyl)-3-methylurea;1-Methyl-3-(4-fluorophenyl)urea
• CAS NO: 772-55-4
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.17
• Mol File: 772-55-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 230.8°C at 760 mmHg
• Flash Point: 93.4°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.0647mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-Methyl-3-(4-fluorophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-(4-fluorophenyl)urea(772-55-4)
• EPA Substance Registry System: 1-Methyl-3-(4-fluorophenyl)urea(772-55-4)

Safety Data

• Hazardous Substances Data: 772-55-4(Hazardous Substances Data)

Usage

Chemical composition

Consists of a methyl group, a urea group, and a 4-fluorophenyl group.

Physical form

White crystalline solid.

Solubility

Soluble in organic solvents.

Potential use as a herbicide

Inhibits plant growth by interfering with photosynthesis.

Pharmaceutical properties

Has been investigated as a potential anti-inflammatory agent.

InChI:InChI=1/C8H9FN2O/c1-10-8(12)11-7-4-2-6(9)3-5-7/h2-5H,1H3,(H2,10,11,12)

Upstream product

• 1195-45-5 para-fluorophenyl isocyanate 
• 372-09-8 cyanoacetic acid 
• 74-89-5 methylamine 
• 624-83-9 methyl isocyanate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 19677-81-7 1-(4-fluoro-phenyl)-3-methyl-pyrimidine-2,4,6-trione 
• 176378-95-3 acetic acid 3-acetoxy-5-[6-dimethylamino-1-(4-fluoro-phenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-phenyl ester 
• 301206-18-8 6-dimethylamino-1-(4-fluoro-phenyl)-3-methyl-5-nitro-1H-pyrimidine-2,4-dione 
• 176379-64-9 5-amino-6-dimethylamino-1-(4-fluorophenyl)-3-methyluracil 
• 176379-63-8 6-dimethylamino-1-(4-fluorophenyl)-3-methyl-2,4-(1H,3H)-pyrimidinedione 
• 301206-17-7 6-chloro-1-(4-fluorophenyl)-3-methyluracil 
• 19369-30-3 6-amino-1-(4-fluoro-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 19677-96-4 5,6-diamino-1-(4-fluoro-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 301206-16-6 1-(2-Cyano-acetyl)-3-(4-fluoro-phenyl)-1-methyl-urea 
• 777-59-3 N'-(4-fluorophenyl)-N-methyl-N-nitroso-urea 

Relevant articles and documents

Synthesis and anticonvulsant activity of new N-1′,N-3′-disubstituted-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-triones

Thirteen new N-1′,N-3′-disubstituted-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-triones were synthesized and their pharmacological activity determined with the objective to better understand their SAR for anticonvulsant activity. The anticonvulsant effects of these compounds were evaluated by standard pentylenetetrazol (scPTZ test) and maximum electroshock seizure (MES test) models in mice. Most of the compounds showed ability to protect against the pentylenetetrazol-induced convulsions. Compound 3o (the N-1′-p-nitrophenyl, N-3′-ethyl derivative) in the N-1′-aryl, N-3′-alkyl disubstituted series exhibited maximum activity with ED50 of 41.8 mg/kg in scPTZ convulsion model.

THE SYNTHESIS OF ANTINEOPLASTIC AGENTS. XXXII. N-NITROSOUREAS. I.

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