176502-43-5

Basic information

• Product Name: methyl 2-(1-oxoethyl)-7-phenyl-6-heptynoate
• Synonyms: methyl 2-(1-oxoethyl)-7-phenyl-6-heptynoate
• CAS NO: 176502-43-5
• Molecular Weight: 258.317
• Mol File: 176502-43-5.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-(1-oxoethyl)-7-phenyl-6-heptynoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(1-oxoethyl)-7-phenyl-6-heptynoate(176502-43-5)
• EPA Substance Registry System: methyl 2-(1-oxoethyl)-7-phenyl-6-heptynoate(176502-43-5)

Safety Data

• Hazardous Substances Data: 176502-43-5(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 131190-10-8 methyl 2-acetyl-6-heptynoate 
• 28077-72-7 1-bromo-4-pentyne 
• 105-45-3 acetoacetic acid methyl ester 
• 34886-50-5 (5-iodopent-1-yn-1-yl)benzene 
• 57718-13-5 (5-bromo-pent-1-ynyl)-benzene 

Downstream Products

• 131190-09-5 methyl 1-(1-oxoethyl)-2-(phenylmethylidene)cyclopentanecarboxylate 
• 1092110-41-2 methyl 1-acetyl-2-phenylcyclohexanecarboxylate 
• 1067674-31-0 methyl 1-acetyl-2-phenyl-2-cyclohexenecarboxylate 
• 1067674-22-9 (Z)-methyl 1-acetyl-2-benzylidenecyclopentanecarboxylate 

Relevant articles and documents

Iodobenzene-catalyzed intramolecular oxidative cyclization reactions of ss-Alkynyl β-Ketoesters

Chemical equations presented. Iodobenzene is shown to catalyze the 5-exo-dig cyclization of ss-alkynyl β-ketoesters under oxidative conditions that generate hypervalent iodine species in situ. The cyclopentane products contain adjacent quaternary and tertiary stereocenters which are generated with excellent diastereoselectivity.

Cyclization of nonterminal alkynic β-Keto esters catalyzed by gold(I) complex with a semihollow, end-capped triethynylphosphine ligand

(Chemical Equation Presented) A cationic gold(I) complex with a semihollow-shaped trialkynylphosphine catalyzed 5-exo-dig and 6-endo-dig cyclizations of various internal alkynic β-keto esters, showing a marked advantage over a gold(I) - PPh3 complex with respect to the rates of the reactions and the product yields. It is proposed that the gold-bound alkynic substrate in a catalytic pocket must be somewhat folded and that such a steric effect makes the carbon-carbon bond formation entropically more favorable.

New cobalt-catalyzed cycloisomerization of ε-acetylenic β-keto esters. Application to a powerful cyclization reactions cascade

The full details of investigations into the cobalt(I)-catalyzed ene type reaction of ε-acetylenic β-keto esters to form highly functionalized methylenecyelopentanes are described. The observed regio-, chemo-, and stereoselectivities support a process of cycloisomerization which controls the relative stereochemistry of two contiguous stereogenic centers. An efficient route to the basic skeleton of the phyllocladane family has been achieved via a one-pot sequence of cyclizations: ene type, [2 + 2 + 2], [4 + 2]. This new cascade created six carbon-carbon bonds and four rings in a totally stereoselective manner from an easily accessible acyclic polyunsaturated precursor.