1766-57-0

Basic information

• Product Name: Benzenesulfonamide, N-(2-fluorophenyl)-4-nitro-
• CAS NO: 1766-57-0
• Molecular Formula: C12H9FN2O4S
• Molecular Weight: 296.279
• Mol File: 1766-57-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-fluorophenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-fluorophenyl)-4-nitro-(1766-57-0)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-fluorophenyl)-4-nitro-(1766-57-0)

Safety Data

• Hazardous Substances Data: 1766-57-0(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1494-83-3 4-amino-N-(2-fluorophenyl)-benzenesulfonamide 
• 1978-38-7 2-fluoro-N-methylaniline 
• 900537-29-3 N-methyl-N-nosyl-o-fluoroaniline 

Relevant articles and documents

Palladium-catalyzed intramolecular oxidative coupling involving double C(sp2)-H bonds for the synthesis of annulated biaryl sultams

The palladium-catalyzed intramolecular oxidative coupling described herein involves a double C(sp2)-H bond functionalization in sulfonanilides, providing a workable access to biaryl sultams annulated into a six-membered ring that are otherwise difficult to obtain by literature methods. The other synthetic applications of this protocol including the synthesis of biaryl sultams containing a seven-membered ring and analogous sultones are also presented.

INHIBITORS OF RAC1 AND USES THEREOF FOR INDUCING BRONCHODILATATION

The present invention concerns a compound having the following formula (I): wherein: - A is in particular -N(R'a)-C(=O)-R, R'a being H or a (C1-C6)alkyl group, and R being preferably a group having the following formula (II): - X is in particular chosen from the group consisting of: -SO2-N(R'b)-, R'b being H or a (C1-C6)alkyl group, -N(R"b)-SO2-, R"b being H or a (C1-C6)alkyl group, -CO-NH-, and -NH-CO-, for use for the treatment of pathologies characterized by bronchoconstriction, such as asthma.

Highly specific N-monomethylation of primary aromatic amines

A synthetic methodology for the specific conversion of primary aromatic amines into their N-monomethyl derivatives under very mild conditions is presented. Anilines are treated with 4-nitrobenzenesulfonyl (nosyl) chloride to generate the corresponding sulfonamides 2 in high yields. The subsequent N-methylation reaction of the sulfonamides 2 with a solution of diazomethane is rapid and quantitative. Removal of the nosyl protecting group is readily carried out using the reagent system mercaptoacetic acid/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) affording the N-monomethylated aromatic amines 4. The procedure is convenient, efficient, and gives rise to the N-monomethyl-anilines exclusively.