900537-29-3

Basic information

• Product Name: Benzenesulfonamide, N-(2-fluorophenyl)-N-methyl-4-nitro-
• CAS NO: 900537-29-3
• Molecular Formula: C13H11FN2O4S
• Molecular Weight: 310.306
• Mol File: 900537-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-fluorophenyl)-N-methyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-fluorophenyl)-N-methyl-4-nitro-(900537-29-3)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-fluorophenyl)-N-methyl-4-nitro-(900537-29-3)

Safety Data

• Hazardous Substances Data: 900537-29-3(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 1766-57-0 N-(2-fluorophenyl)-4-nitrobenzenesulfonamide 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 3406-75-5 2-(4-nitrophenylthio)acetic acid 
• 1978-38-7 2-fluoro-N-methylaniline 

Relevant articles and documents

Highly specific N-monomethylation of primary aromatic amines

A synthetic methodology for the specific conversion of primary aromatic amines into their N-monomethyl derivatives under very mild conditions is presented. Anilines are treated with 4-nitrobenzenesulfonyl (nosyl) chloride to generate the corresponding sulfonamides 2 in high yields. The subsequent N-methylation reaction of the sulfonamides 2 with a solution of diazomethane is rapid and quantitative. Removal of the nosyl protecting group is readily carried out using the reagent system mercaptoacetic acid/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) affording the N-monomethylated aromatic amines 4. The procedure is convenient, efficient, and gives rise to the N-monomethyl-anilines exclusively.