176652-07-6 Usage
Description
Artemisinin-d3 is a crystalline solid that serves as an internal standard for the quantification of artemisinin, an endoperoxide antimalarial agent with anticancer activity. It is derived from the traditional Chinese medicinal herb Artemisia annua L., which has been known for almost 2000 years as Qinghao.
Uses
1. Used in Pharmaceutical Industry:
Artemisinin-d3 is used as an internal standard for the quantification of artemisinin, which is an active antimalarial constituent. This helps in the accurate measurement and analysis of artemisinin in various formulations and treatments.
2. Used in Antimalarial Applications:
Artemisinin-d3 is used as a reference compound for the development and evaluation of antimalarial drugs. Artemisinin, the compound it quantifies, has been proven effective in reducing the growth of various P. falciparum strains in vitro and parasitemia in mice infected with P. falciparum.
3. Used in Anticancer Applications:
Artemisinin-d3 is used as a reference compound for the study of artemisinin's anticancer activity. Artemisinin has been shown to induce cell cycle arrest, apoptosis, and inhibit the growth of various neuroblastoma cell lines in a timeand concentration-dependent manner.
4. Used in Drug Delivery Systems:
Artemisinin-d3 can be used as a reference compound in the development of novel drug delivery systems for artemisinin. These systems aim to improve the delivery, bioavailability, and therapeutic outcomes of artemisinin in the treatment of malaria and cancer.
5. Used in Combination Therapies:
Artemisinin-d3 is used as a reference compound in the development and evaluation of combination therapies for the treatment of malaria. Formulations containing artemisinin have been used in combination with other drugs to enhance their efficacy and overcome drug resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 176652-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,6,5 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 176652-07:
(8*1)+(7*7)+(6*6)+(5*6)+(4*5)+(3*2)+(2*0)+(1*7)=156
156 % 10 = 6
So 176652-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1/i2D3
176652-07-6Relevant articles and documents
Deuterated antimalarials: Synthesis of trideutero- artemisinin, dihydroartemisinin, and arteether
Avery, Mitchell A.,Bonk, Jason D.,Mehrotra, Sanjiv
, p. 249 - 254 (2007/10/03)
The stereoselective total synthesis of the antimalarial agents artemisinin-d3 (1), dihydroartemisinin-d3 (2), and arteether-d3 (3), incorporating 2H at C-16 (C-9 methyl) is reported.
