176721-01-0

Basic information

• Product Name: α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
• Synonyms: 1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)methanol;alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;(2,3-diMethylphenyl)(1-trityl-1H-iMidazol-4-yl)Methanol;1H-IMidazole-4-Methanol, α-(2,3-diMethylphenyl)-1-(triphenylMethyl)-;(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol;(2,3-Dimethylphenyl)-(3-trityl-3H-imidazol-4-yl)methanol
• CAS NO: 176721-01-0
• Molecular Formula: C₃₁H₂₈N₂O
• Molecular Weight: 444.56682
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 176721-01-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 616.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated), Ethy
• PKA: 13.08±0.20(Predicted)
• CAS DataBase Reference: α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol(176721-01-0)
• EPA Substance Registry System: α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol(176721-01-0)

Safety Data

• Hazardous Substances Data: 176721-01-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 176721-01-0 differently. You can refer to the following data:
1. α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol is an Intermediate in the production of Medetomidine
2. Intermediate in the production of Medetomidine

Upstream product

• 576-23-8 2,3-dimethylbromobenzene 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 5779-93-1 2,3-dimethylbenzaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 

Downstream Products

• 176721-04-3 (S)-dexmedetomidine-L-(+)-tartrate 
• 86347-14-0 (+/-)-4(5)-<1-(2,3-Dimethylphenyl)ethyl-1H-imidazole> 
• 1021949-47-2 1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene 
• 176721-02-1 4-<(2,3-dimethylphenyl)carbonyl>-1-(triphenylmethyl)imidazole 
• 176721-03-2 4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole 
• 113775-47-6 dexmedetomidine 
• 86347-14-0 medetomidine 

Relevant articles and documents

A right-US supporting [...] and its hydrochloride preparation method

Invention provides a right-US supporting [...] and its hydrochloride preparation method. In particular, the invention using carbon-carbon hydrogenation reduction catalyst and (R, S) - Duanphos composition as a catalyst to the double bond of a chiral catalytic reduction, directly by the enantiomeric excess percentage up to 99.9% of the right us holds the onamot to decide, the preparation method of the present invention short synthetic route, the product does not need to chiral separation, high yield.

A novel and facile route for the synthesis of medetomidine as the α2-adrenoceptor agonist

Abstract: We report here a novel and facile method for the synthesis of (±)-4(5)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole (medetomidine) in a good yield in five steps. The method involves Wittig olefination of the phenylimidazolylketones, followed by a hydrogenation. We demonstrate that the Wittig alkenylation reaction provides a convenient step for the synthesis of medetomidine without requiring methylation and dehydration steps, which are problematic processes in the previous methods. Graphical Abstract: Novel route for the synthesis of medetomidine.[Figure not available: see fulltext.].

Efficient synthesis of (S)-4(5)-[1-(2,3-dimethylphenyl) ethyl]imidazole tartrate, the potent α2 adrenoceptor agonist dexmedetomidine

(S,R)-4(5)-[1-(2,3-dimethylphenyl)ethyl]imidazole 5 is prepared in 41% yield, by a new reliable method from readily available starting materials. The separation of the enantiomers proceeds through the selective crystallisation of the (+)-tartrate of the (S) enantiomer 6 in the presence of the (R) enantiomer free base.