176721-02-1

Basic information

• Product Name: (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone
• Synonyms: (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone;(2,3-Dimethylphenyl)[1-(triphenylmethyl)-1H-imidazol-4-yl]methanone;(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone;(2,3-Dimethylphenyl)-(3-trityl-3H-imidazol-4-yl)methanone;1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)methanone
• CAS NO: 176721-02-1
• Molecular Formula: C₃₁H₂₆N₂O
• Molecular Weight: 442.55094
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 176721-02-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.09
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone(176721-02-1)
• EPA Substance Registry System: (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone(176721-02-1)

Safety Data

• Hazardous Substances Data: 176721-02-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

(2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone is used in the synthetic preparation of dexmedetomidine from medetomidine intermediate.

Upstream product

• 576-23-8 2,3-dimethylbromobenzene 
• 76074-88-9 methyl 1-(triphenylmethyl)-1H-imidazole-4-carboxylate 
• 53525-60-3 4-carbethoxy-1-triphenyl methyl-1H-imidazole 
• 76-83-5 trityl chloride 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 176721-01-0 4-<(2,3-dimethylphenyl)hydroxymethyl>-1-(triphenylmethyl)imidazole 

Downstream Products

• 176721-03-2 4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole 
• 176721-04-3 (S)-dexmedetomidine-L-(+)-tartrate 
• 113775-47-6 dexmedetomidine 
• 86347-14-0 medetomidine 
• 86347-14-0 (+/-)-4(5)-<1-(2,3-Dimethylphenyl)ethyl-1H-imidazole> 
• 1021949-47-2 1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene 

Relevant articles and documents

A right-US supporting [...] and its hydrochloride preparation method

Invention provides a right-US supporting [...] and its hydrochloride preparation method. In particular, the invention using carbon-carbon hydrogenation reduction catalyst and (R, S) - Duanphos composition as a catalyst to the double bond of a chiral catalytic reduction, directly by the enantiomeric excess percentage up to 99.9% of the right us holds the onamot to decide, the preparation method of the present invention short synthetic route, the product does not need to chiral separation, high yield.

Preparation method of dexmedetomidine hydrochloride and its intermediate

The invention discloses a preparation method of dexmedetomidine hydrochloride and its intermediate. A preparation method of dexmedetomidine L-tartrate comprises the steps of subjecting dexmedetomidineintermediate III and hydrogen to reduction reaction in an organic solvent in the presence of a chiral catalyst, and subjecting the reduced product and tartaric acid to neutralization reaction to obtain dexmedetomidine L-tartrate II, wherein the chiral catalyst is (+)-1,2-bis(2S-5S)-diethylphospholano-benzene(1,5-cyclooctadiene)rhodium trifluoromethanesulfonate. The preparation method herein has ashort step path, has no need for chiral splitting, and has high total molar yield; the product prepared herein has high purity, reaches the standard for bulk pharmaceutical chemicals and is suitablefor industrial production.

PREPARATION METHOD OF DEXMEDETOMIDINE INTERMEDIATE

The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1H-imidazole