176747-44-7

Upstream product

• 1041199-38-5 (2S,4R)-ethyl 4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate 
• 83487-17-6 (2S,4R)-(-)-N-methyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 845965-30-2 (6R,7aS)-6-Hydroxy-1,1-diphenyl-tetrahydro-pyrrolo[1,2-c]oxazol-3-one 
• 108-86-1 bromobenzene 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1217168-92-7 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone 
• 1217168-96-1 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(6-methylpyridin-2-yl)methanone 
• 1217168-95-0 (6-bromopyridin-2-yl)((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone 
• 1217168-93-8 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(5-methoxypyridin-2-yl)methanone 
• 1217168-94-9 ((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(5-nitropyridin-2-yl)methanone 
• 1173184-14-9 trans-4-hydroxy-α,α-diphenyl-L-prolinol hydrochloride 
• 1231764-55-8 C₂₃H₃₃NO₂Si 

Relevant academic research and scientific papers

H-bond-directing organocatalyst for enantioselective [4 + 2] cycloadditions via dienamine catalysis

An efficient, highly regio- and stereoselective [4 + 2] cycloaddition reaction to generate tetrahydropyranopyrazole frameworks has been developed. To this end, a dienamine-based catalytic strategy that relies on the H-bond-directing effect of the hydroxy group of a dinaphthylprolinol-type aminocatalyst has been used. This enables the synthesis of multifunctionalized heterocyclic derivatives with three contiguous stereocenters in good yields and excellent enantioselectivities.

A new organocatalytic concept for asymmetric -alkylation of aldehydes

The organocatalytic asymmetric -alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts,-diarylmethine-substituted aldehydes with two contiguo

NOVEL NI COMPLEX AND ITS DERIVATIVES, PRODUCING METHOD, AND THE USE THEREOF AS AN ANTIOXIDANT

The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicines, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.

A general approach for preparation of polymer-supported chiral organocatalysts via acrylic copolymerization

(Figure Presented) Polymer-supported chiral organocatalysts, as well as most other forms of immobilized catalysts, are traditionally prepared by a postmodification approach where modified catalyst precursors are anchored onto prefabricated polymer beads. Herein, we report an alternative and more scalable approach where polymer-supported chiral enamine and iminium organocatalysts are prepared in a bottom-up fashion where methacrylic functional monomers are prepared in an entirely nonchromatographic manner and subsequently copolymerized with suitable comonomers to give cross-linked polymer beads. All syntheses have been conducted on multigram scale for all intermediates and finished polymer products, and the catalysts have proven successful in reactions taking place in solvents spanning a wide range of solvent polarity. While polymer-supported proline and prolineamides generally demonstrated excellent results and recycling robustness in asymmetric aldol reactions of ketones and benzaldehydes, the simplest type of Joargensen/Hayashi diarylprolinol TMS-ether showed excellent selectivity, but rather sluggish reactivity in the Enders-type asymmetric cascade. The polymer-supported version of the first-generation MacMillan imidazoHdinone had a pattern of reactivity very similar to that of the monomeric catalyst, but is too unstable to allow recycling.

Chiral phosphinooxazolidine ligands for palladium- and platinum-catalyzed asymmetric Diels-Alder reactions

Cationic palladium (Pd)- and platinum (Pt)-phosphinooxazolidine catalysts 13a-c, 15a-d, 17a-c, and 19a-c were prepared from phosphinooxazolidine ligands 1-3, MCl2 (M = Pd and Pt), and counterions, and the activities of the catalysts in the asymmetric Diels-Alder (DA) reactions of cyclic or acyclic dienes with imide dienophiles were investigated. These catalysts demonstrated high levels of catalytic activity. The cationic Pd-POZ complex 13c provided particularly excellent enantioselectivity (98% ee) in the DA reactions of cyclopentadiene with acryloyl-, crotonyl-, and fumaroyl-1,3-oxazolidin-2-ones (20a-c).