1041199-38-5

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 100-58-3 phenylmagnesium bromide 
• 19887-35-5 (2S,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 
• 845965-33-5 1-ethyl 2-methyl (2S,4R)-4-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine-1,2-dicarboxylate 
• 108-86-1 bromobenzene 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 172947-84-1 (2S,4R)-diphenyl-(1-methyl-4-hydroxypyrrolidin-2-yl)methanol 
• 176747-44-7 (2S,4R)-4-hydroxy-α,α-diphenyl-2-pyrrolidinemethanol 
• 1041199-39-6 ethyl (2S,4R)-2-(hydroxy(diphenyl)methyl)-4-(tosyloxy)pyrrolidine-1-carboxylate 
• 845965-31-3 (6R,7aS)-6-methoxy-1,1-diphenyltetrahydropyrrolo[1,2-c]oxazol-3(1H)-one 
• 1218989-18-4 (6R,7aS)-1,1-diphenyl-6-(prop-2-yn-1-yloxy)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one 
• 1218989-20-8 (2S,4R)-2-(diphenyl((trimethylsilyl)oxy)methyl)-4-(prop-2-yn-1-yloxy)pyrrolidine 
• 1218989-19-5 ((2S,4R)-diphenyl-4-(prop-2-yn-1-yloxy)pyrrolidin-2-yl)methanol 
• 1103893-51-1 ((2S,4R)-2(hydroxydiphenylmethyl)-4-methoxypyrrolidin-1-yl)(pyridin-2-yl)methanone 
• 1103893-34-0 ((2S,4R)-4-methoxypyrrolidin-2-yl)diphenylmethanol 

Relevant academic research and scientific papers

Synthesis and Crystal Structure Characterization of (6 R,7a S)-1,1-Diphenyl-6-(4-vinylbenzyloxy)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

The title compound, (6R,7aS)-1,1-Diphenyl-6-(4-vinylbenzyloxy)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one, was synthesized and characterized by 1H and 13C NMR and high-resolution mass spectrometry (HRMS). Its molecular configuration was investigated by X-ray crystallography. The crystal structure is devoid of any classical hydrogen bonding, and molecules are linked by weak CH.O contacts. In the 4-vinylbenzyloxy group, the three H atoms and one C atom are disordered over two sets of sites, with site occupancy factors of 0.75 and 0.25.

Solid supported Hayashi–J?rgensen catalyst as an efficient and recyclable organocatalyst for asymmetric Michael addition reactions

A comparison of three different catalytic systems for the efficient, asymmetric synthesis of N-({(3R,4R)-4-[(benzyloxy)methyl]pyrrolidin-3-yl}methyl)-N-(2-methylpropyl)benzenesulfonamide 1 (BZN) is described. The presented strategy is based on the organocatalytic Michael addition of aldehyde 2 to trans-nitroalkene 3, and subsequent reductive cyclization. High yields, enantio-, and diastereoselectivities were achieved in the Michael addition by application of a POSS- or Wang resin-supported Hayashi–J?rgensen catalyst.

H-bond-directing organocatalyst for enantioselective [4 + 2] cycloadditions via dienamine catalysis

An efficient, highly regio- and stereoselective [4 + 2] cycloaddition reaction to generate tetrahydropyranopyrazole frameworks has been developed. To this end, a dienamine-based catalytic strategy that relies on the H-bond-directing effect of the hydroxy group of a dinaphthylprolinol-type aminocatalyst has been used. This enables the synthesis of multifunctionalized heterocyclic derivatives with three contiguous stereocenters in good yields and excellent enantioselectivities.

Enantioselective heterogeneous synergistic catalysis for asymmetric cascade transformations

A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non-metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5:2.5 er) as well as spirocyclic oxindoles (97.5:2.5 to >99:0.5 er), containing all-carbon quaternary centers, in a highly enantioselective fashion via a one-pot dynamic relay process.

NOVEL NI COMPLEX AND ITS DERIVATIVES, PRODUCING METHOD, AND THE USE THEREOF AS AN ANTIOXIDANT

The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicines, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.

Efficient, enantioselective iminium catalysis with an immobilized, recyclable diarylprolinol silyl ether catalyst

(Figure Presented) A highly efficient approach for the synthesis, application, and recycling of immobilized diarylprolinol silyl ethers was developed. The MeOPEG-supported Jorgensen-Hayashi catalyst provides unchanged reactivity and selectivity as compared to the homogeneous catalyst, as demonstrated for the Michael addition of nitromethane to α,β- unsaturated aldehydes via iminium activation. In addition, the immobilization allows for a simple, column-free isolation of pure, sensitive aldehyde products and therefore may be useful for application in more complicated syntheses.

Highly enantioselective synthesis of β-amino acid derivatives by the lewis base catalyzed hydrosilylation of β-enamino esters

A study was conducted to demonstrate highly enantioselective synthesis of β-amino acid derivatives by the Lewis base catalyzed hydrosilylation of βenamino esters. It was found that these catalyst and its analogue displayed excellent activities and enantioselectivities in promoting hydrosilylation of N-aryl β-enamino esters. N-picolinoylpyrrolidine derivatives and N-picolioylephedrine were also evaluated in hydrosilylation of (Z)-methyl 3-phenyl-3-(phenylamino)acrylate. The generality of the Lewis base organocatalyzed hydrosilylation of various β-enamino esters were examined under the optimized conditions. It was observed that the catalytic system exhibited a high sensitivity to the N-substituents, while all the N-aryl β-enamino esters underwent the hydrosilylation smoothly to give corresponding β-amino esters.

1,2,3-Triazole-linked dendrimers as a support for functionalized and recoverable catalysts for asymmetric borane reduction of prochiral ketones

A series of new, functionalized, and chiral catalysts have been synthesized based on 1,2,3-triazole-linked dendrimers. It has been found that dendrimer 7f is an efficient catalyst for the enantioselective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were obtained (up to 96%). The catalyst can be recovered and reused four times without a significant loss of catalytic activity.

Chiral phosphinooxazolidine ligands for palladium- and platinum-catalyzed asymmetric Diels-Alder reactions

Cationic palladium (Pd)- and platinum (Pt)-phosphinooxazolidine catalysts 13a-c, 15a-d, 17a-c, and 19a-c were prepared from phosphinooxazolidine ligands 1-3, MCl2 (M = Pd and Pt), and counterions, and the activities of the catalysts in the asymmetric Diels-Alder (DA) reactions of cyclic or acyclic dienes with imide dienophiles were investigated. These catalysts demonstrated high levels of catalytic activity. The cationic Pd-POZ complex 13c provided particularly excellent enantioselectivity (98% ee) in the DA reactions of cyclopentadiene with acryloyl-, crotonyl-, and fumaroyl-1,3-oxazolidin-2-ones (20a-c).

New chiral heterogeneous catalysts based on mesoporous silica: Asymmetric diethylzinc addition to benzaldehyde

New heterogeneous catalyst systems have been developed employing a proline-derived ligand immobilized on mesoporous silicas; asymmetric diethylzinc addition to benzaldehyde was carried out using the catalyst systems; the reaction enantioselectivity was fo