176791-06-3Relevant academic research and scientific papers
A reaction for sp3-sp3 C-C bond formation via cooperation of Lewis acid-promoted/Rh-catalyzed C-H bond activation
Shi, Lei,Tu, Yong-Qiang,Wang, Min,Zhang, Fu-Min,Fan, Chun-An,Zhao, Yu-Ming,Xia, Wu-Jiong
, p. 10836 - 10837 (2007/10/03)
A new method for intermolecular sp3-sp3 C-C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3 (cat.)/BF3·OEt2 (2.5 equiv)/BuBr (0.5 equiv)/toluene system was first disclosed, which possessed quite significant utilities for organic synthesis, especially for that of secondary alcohols. The most significant aspect is the discovery that rhodium-catalyzed C-H bond activation of alcohols is feasible under Lewis acid-promoted conditions. Copyright
