176796-98-8Relevant academic research and scientific papers
Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives
Barth, Martine M.,Binet, Jean L.,Thomas, Didier M.,De Fornel, Daniel C.,Samreth, Soth,Schuber, Francis J.,Renaut, Patrice P.
, p. 2302 - 2312 (1996)
2,3-Oxidosqualene lanosterol-cyclase (OSC; EC 5.4.99.7) is an attractive target for the design of compounds that block hepatic cholesterol biosynthesis. (4aα,5α,6β,8aβ)-Decahydro-5,8a-dimethyl-2-(1,5,9- trimethyldecyl)-6-isoquinolinol (1) and simplified a
