176852-08-7Relevant academic research and scientific papers
The preparation of substituted 1(2H)-isoquinolinones from polylithiated 2-(2-methylphenyl)hydrazinecarboxylic acid esters
Koller, Madlene U.,Church, A. Cameron,Griffith, Cynthia L.,Hines, Margaret A.,Lachicotte, Rene J.,Taylor, Richard A.,Beam, Charles F.
, p. 1763 - 1774 (2007/10/03)
2-(2-methylphenyl)hydrazinecarboxylic acid esters were metalated with excess lithium diisopropylamide, and the resulting polyanion-type intermediates were condensed with aromatic esters followed by acid cyclization to the 3-substituted-1(2H)-isoquinolinon
