176852-91-8

Upstream product

• 4815-38-7 ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 
• 333-20-0 potassium thioacyanate 
• 4815-39-8 2-amino-4-methyl-5-phenyl-thiophen-3-carboxamide 
• 463-71-8 thiophosgene 

Downstream Products

• 176852-94-1 3-(5-Methyl-4-oxo-6-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidin-2-ylsulfanyl)-pentane-2,4-dione 
• 1213791-73-1 2-(ethylthio)-5-methyl-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one 
• 176853-16-0 3-[(5-Methyl-4-oxo-6-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidin-2-yl)-hydrazono]-butyric acid ethyl ester 
• 176852-98-5 2-Acetyl-3,6-dimethyl-7-phenyl-thiazolo[3,2-a]thieno[2,3-d]pyrimidin-5-one 

Relevant academic research and scientific papers

Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized. We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, 5a,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids. All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 μM at the GluR6 receptor.

Synthesis and Reaction of Some Thienopyrimidine Derivatives and Some of Their Photooxidation

The fact that many thienopyrimidine derivatives were established as antiulcer agents, hypocholesterolemic drugs, sedatives antitussives, bactericidal against streptococcus and as fungicidal against pythium has led us to synthesize some of their new derivatives.